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This study aims to explore the downstream regulating pathway of FGF23 in postmenopausal osteoporosis. The rat model of osteoporosis was established through ovariectomy (OVX). The investigation demonstrated that the serum levels of FGF23 and the phosphorylation levels of JAK2, STAT1, and STAT3 were up\u2010regulated in the OVX\u2009+\u2009NVP\u2010BGJ398 group while were down\u2010regulated in the OVX\u2009+\u2009Anti\u2010FGF23 group than that in the OVX group. Moreover, the JAK2\/STAT1\/3 inhibitor, AG490 promoted the OVX\u2010induced increase in the osteocalcin, ALP, BALP, TRAP, and CTX\u2010I levels. Besides, AG490 enhanced cartilage lesions and increased TUNEL\u2010positive chondrocytes in the OVX group. In addition, higher protein expression of MMP\u20101 and MMP\u201013 and lower expression of COX\u2010II were observed in the OVX\u2009+\u2009AG490 group than that in the OVX group. Our findings suggested that FGF23 was involved in the progression of osteoporosis via the JAK\/STAT signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26332","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T09:58:39Z","timestamp":1502099919000},"page":"3819-3828","source":"Crossref","is-referenced-by-count":36,"title":["The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK\/STAT pathway"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-008X","authenticated-orcid":false,"given":"Lijun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaigang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"260","article-title":"Guidelines for the diagnosis, prevention and treatment of osteoporosis","volume":"61","author":"Romani L","year":"2009","journal-title":"Reumatismo"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp043801"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112845"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2012.0535"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03299891"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2014.1000372"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1565-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000154"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.05.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3528"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.478"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1810"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3340297"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.01.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.193896"},{"key":"e_1_2_6_17_1","first-page":"941","article-title":"Role of the JAK\u2010STAT pathway in proliferation and differentiation of human hypertrophic scar fibroblasts induced by connective tissue growth factor","volume":"3","author":"Tao L","year":"2010","journal-title":"Mol Med Rep"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs106"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.9.5364"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.05.007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.04.020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11434"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.09.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.06.007"},{"key":"e_1_2_6_25_1","first-page":"164","article-title":"Animal models for bone and joint disease. 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