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Though oral rehydration therapy is the preferred choice of treatment, the use of antibiotics could reduce the microbial load in the case of severity. The use of antibiotics is also sought in the scenarios where there is problem with access to clean water. However, <jats:italic>Vibrio cholera<\/jats:italic> (<jats:italic>V. cholerae<\/jats:italic>) strains have developed resistance to antibiotics such as amoxicillin, ampicillin, chloramphenicol, doxycycline, erythromycin, and tetracycline. In this work, we have addressed the resistance issue by targeting MurB protein which is essential for the cell wall biosynthesis in <jats:italic>V. cholerae<\/jats:italic>. 20 Phytochemical compounds were chosen to screen the potential inhibitors against <jats:italic>V. cholerae<\/jats:italic> to avoid the complications faced by synthesis of small molecules. The molecular docking and dynamics study indicates that quercetin is the most potential and stable inhibitor of Murb.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26333","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T05:12:41Z","timestamp":1502169161000},"page":"1726-1732","source":"Crossref","is-referenced-by-count":43,"title":["MurB as a target in an alternative approach to tackle the <i>Vibrio cholerae<\/i> resistance using molecular docking and simulation study"],"prefix":"10.1002","volume":"119","author":[{"given":"Adhithya","family":"Ragunathan","sequence":"first","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kullappan","family":"Malathi","sequence":"additional","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-7488","authenticated-orcid":false,"given":"Anand","family":"Anbarasu","sequence":"additional","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.07.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.48"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1111.041170"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1996.d01-54.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004053"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01571061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00035-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02026-08"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15328-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.5481909.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.11.2822-2829.1988"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-50-10-879"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899003957"},{"key":"e_1_2_8_16_1","first-page":"241","article-title":"Emergence of multidrug\u2010resistant strain of Vibrio cholerae O1 in Bangladesh and reversal of their susceptibility to tetracycline after two years","volume":"25","author":"Faruque AS","year":"2007","journal-title":"J Health Popul Nutr"},{"key":"e_1_2_8_17_1","first-page":"564","article-title":"Increased isolation of Vibrio cholerae O1 serotype Inaba over serotype Ogawa in Pakistan","volume":"14","author":"Jabeen K","year":"2008","journal-title":"East Mediterr Health J"},{"key":"e_1_2_8_18_1","first-page":"613","article-title":"Epidemiology & antibiograms of Vibrio cholerae isolates from a tertiary care hospital in Chandigarh, north India","volume":"129","author":"Chander J","year":"2009","journal-title":"Indian J Med Res"},{"key":"e_1_2_8_19_1","first-page":"768","article-title":"Survey of antibiogram tests in cholera patients in the 2005 epidemic in Hamadan, Islamic Republic of Iran","volume":"14","author":"Keramat F","year":"2008","journal-title":"East Mediterr Health J"},{"key":"e_1_2_8_20_1","first-page":"23","article-title":"Antimicrobial suceptibility of V. cholerae in northwest. 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