{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:28:13Z","timestamp":1776986893005,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["14JJ2026"],"award-info":[{"award-number":["14JJ2026"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cervical cancer still remains the fourth most common cancer, affecting women worldwide with large geographic variations in cervical cancer incidence and mortality rates. SH3\u2010domain binding protein\u20101 (SH3BP1) specifically inactivating Rac1 and its target Wave2 is required for cell motility, thus regarded as an essential regulator of cancer cell metastasis. However, the exact effects and molecular mechanisms of SH3BP1 in cervical cancer progression are still unknown. The present study is aimed to investigate the mechanism of SH3BP1 in regulation of cervical cancer cell metastasis and chemoresistance. In the present study, we demonstrated a high SH3BP1 expression in cervical cancer tissues; a higher SH3BP1 expression is also correlated with a shorter overall survival of patients with cervical cancer. Further, we revealed that SH3BP1 overexpression promoted the invasion, migration, and chemoresistance of cervical cancer cell through increasing Rac1 activity and Wave2 protein level. The promotive effect of SH3BP1 could be partially reversed by a Rac1 inhibitor, NSC 23766. In cisplatin\u2010resistant cervical cancer tissues, SH3BP1, Rac1, and Wave2 mRNA expression was significantly up\u2010regulated compared to that of the cisplatin\u2010sensitive cervical cancer tissues. Taken together, SH3BP1\/Rac1\/Wave2 pathway may potentially act as an effective therapeutic target combined with traditional cisplatin\u2010based chemotherapy for cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26334","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T05:12:40Z","timestamp":1502169160000},"page":"1733-1745","source":"Crossref","is-referenced-by-count":24,"title":["SH3BP1\u2010induced Rac\u2010Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin"],"prefix":"10.1002","volume":"119","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xishan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-4588","authenticated-orcid":false,"given":"Wen","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Xiangya Hospital Central South University Changsha P.R. 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