{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:19:44Z","timestamp":1767136784244,"version":"build-2238731810"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aimed to explore effects of CNP on ventricular remodeling following myocardial ischemia\u2010reperfusion (I\/R) injury through the NPRB\/cGMP signaling pathway. Rat cardiomyocytes were assigned into: control, I\/R, I\/R\u2009+\u2009CNP, and I\/R\u2009+\u20098\u2010Br\u2010cGMP groups. ELISA, qRT\u2010PCR, and Western blotting were used to detect cGMP content and expression, respectively. After model establishment of I\/R rats, normal control, CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      control, I\/R, and CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      groups were set. Indexes of heart were detected using echocardiography and hemodynamics. ELISA was used to measure serum CNP, cGMP, LDH, cTn I, CK\u2010MB, TNF\u2010\u03b1, and IL\u20106 levels. Myocardial infarct was identified by TTC staining, and apoptosis conditions by TUNEL staining. QRT\u2010PCR and Western blotting were adopted to detect expressions of CNP, NPRB, cGMP, and apoptosis\u2010related genes. Compared with control group, cGMP contents and expression in the I\/R, I\/R\u2009+\u2009CNP and I\/R\u2009+\u20098\u2010Br\u2010cGMP groups were decreased. Levels of LVEDV, LVESV, LVDS, LVDD, IVSD, LVM, LVEDP, and LVSP were higher in the I\/R, CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      control, and CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      groups than normal control group while LVEF, SV, CO, and \u00b1dp\/dtmax were lower. Compared with the normal control group, LDH, cTn I, CK\u2010MB, TNF\u2010\u03b1, and IL\u20106 were higher in the I\/R, CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      control and CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      groups; pathological changes and myocardial infarction were observed in the I\/R, CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      control, and CNP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      groups; expressions of apoptosis\u2010related genes in those groups were higher; while CNP, NPRB, cGMP, and Bcl\u20102 expressions were decreased. We came to the conclusion that gene knockdown of CNP blocks the NPRB\/cGMP signaling pathway, thereby aggravating myocardial I\/R injury and causing ventricular remodeling in rats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26341","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T07:52:49Z","timestamp":1502351569000},"page":"1804-1818","source":"Crossref","is-referenced-by-count":7,"title":["<i>Retracted<\/i>\n                    : Effects of gene knockdown of CNP on ventricular remodeling after myocardial ischemia\u2010reperfusion injury through NPRB\/Cgmp signaling pathway in rats"],"prefix":"10.1002","volume":"119","author":[{"given":"Lian\u2010He","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Jining No.1 People's Hospital Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dongying City People's Hospital Dongying China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Jining No.1 People's Hospital Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010Yu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Jining No.1 People's Hospital Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Chi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Jining No.1 People's Hospital Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-0327","authenticated-orcid":false,"given":"Cun\u2010Jian","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Jining No.1 People's Hospital Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100286108"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.087"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017442"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.52.388"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108586108"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-015-0152-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32833aec62"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(96)00110-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1260"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2598"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/305258"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22078"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.12.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160796"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000202463.28618.64"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000226094.94877.98"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1428"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.5.R1443"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-64"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030450"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4514"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.136"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.02.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00666.2014"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.09.023"},{"key":"e_1_2_7_29_1","first-page":"21166","article-title":"Effect of dexmedetomidine on myocardial ischemia\u2010reperfusion injury","volume":"8","author":"Chen S","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.11.022"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020477"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.1.H208"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.04.031"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.06.010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.May.23.10"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.38684"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010101)91:1<106::AID-CNCR14>3.0.CO;2-2"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.62"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5049"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.028"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.610758"}],"updated-by":[{"DOI":"10.1002\/jcb.30035","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"record-id":"30270"},{"DOI":"10.1002\/jcb.30035","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000}}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.26341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.26341","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T14:31:09Z","timestamp":1753799469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.26341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jcb.26341"],"URL":"https:\/\/doi.org\/10.1002\/jcb.26341","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}