{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:05:39Z","timestamp":1790157939143,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571055"],"award-info":[{"award-number":["81571055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400902"],"award-info":[{"award-number":["81400902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271225"],"award-info":[{"award-number":["81271225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201039"],"award-info":[{"award-number":["31201039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["811710"],"award-info":[{"award-number":["811710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["13KJA180001"],"award-info":[{"award-number":["13KJA180001"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004030","name":"Jiangsu Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>We aim to investigate the interaction between the EZH2 and the long noncoding RNA (lncRNA) SPRY4\u2010IT1. We also explore their respective effects on human lung adenocarcinoma (LA) cell invasion and migration. Both LA and adjacent normal tissues were obtained from 256 LA patients. SPTY4\u2010IT expression and EZH2 mRNA expressions in tissues and cells were detected by reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR). The siRNAs against SPRY4\u2010IT1 and EZH2 were co\u2010transfected into A549 and H1975 cells. The interaction between SPRY4\u2010IT1 and EZH2 was determined using a RNA pull\u2010down assay and a RNA immunoprecipitation (RIP) assay. A Transwell assay and scratch assay were used to evaluate the cell migration and invasion abilities. The expressions of E\u2010cadherin and Vimentin in the epithelial\u2010mesenchymal transition (EMT) and EZH2 protein expression were detected through western blotting. SPRY4\u2010IT1 expression was observed to be significantly lower, while the expression of EZH2 was higher in the LA tissues than in the adjacent normal tissues. Compared with the HBE cell line, expressions of SPRY4\u2010IT1 in each human LA cell line had decreased, with the lowest observed reduction in the A549 cell line, while EZH2 mRNA and protein expression increased in each human LA cell lines. After SPRY4\u2010IT1\u2010siRNA was transfected into A549 and H1975 cells, invasion and migration abilities were enhanced, in addition to a reduction in the expression of E\u2010cadherin, while expressions of Vimentin exhibited an increased rate. Consequently, we find that EZH2 promotes LA cell invasion and metastasis by inhibiting SPRY4\u2010IT1 expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26344","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T08:12:42Z","timestamp":1502352762000},"page":"1827-1840","source":"Crossref","is-referenced-by-count":23,"title":["<i>Retracted<\/i>: Effects of long noncoding RNA SPRY4\u2010IT1\u2010mediated EZH2 on the invasion and migration of lung adenocarcinoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Xin","family":"Wen","sequence":"first","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Rui","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Hua","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"},{"name":"School of Environment Science and Spatial Informatics China University of Mining and Technology Xuzhou P. R. China"},{"name":"Jiangsu Key Laboratory for Eco\u2010Agricultural Biotechnology around Hongze Lake School of Life Sciences Huaiyin Normal University Huaian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Shan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Qiu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology Cangzhou Central Hospital Cangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Hua","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Oncology Cangzhou Central Hospital Cangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-0785","authenticated-orcid":false,"given":"Dong\u2010Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Lin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science Jiangsu Normal University Xuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13385"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.04.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0802"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.030"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2638"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210662"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0869-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.05.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11606"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04431"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.333"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.05.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12702"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-012-0897-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1863"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.256"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4460"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.12.005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31812f3c1a"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv238"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2015.07.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0595-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2012.08.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0090-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.305095166"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v4.i4.128"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12382"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37183"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.102"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.2.1.15114"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-016-9341-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-012-4413-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1916"}],"updated-by":[{"DOI":"10.1002\/jcb.30036","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"record-id":"30271"},{"DOI":"10.1002\/jcb.30036","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000}}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.26344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.26344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T14:31:08Z","timestamp":1753799468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.26344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jcb.26344"],"URL":"https:\/\/doi.org\/10.1002\/jcb.26344","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1002\/jcb.30036","asserted-by":"object"}]},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}