{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:01:25Z","timestamp":1790391685569,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>This study aims to explore the role of long noncoding RNA (lncRNA)\u2010HOX transcript antisense intergenic RNA (HOTAIR) in the occurrence and progression of glioma. Fresh glioma and normal brain tissues were classified into a glioma group (<jats:italic>n<\/jats:italic>\u2009=\u200967) and a normal group (<jats:italic>n<\/jats:italic>\u2009=\u200964) respectively. U87 cells were assigned into the blank, sh\u2010NC, and sh\u2010HOTAIR groups. Quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) was utilized to determine HOTAIR expression. Cell proliferation, cell cycle and cell apoptosis rates were detected by cell counting kit\u20108 (CCK\u20108) and flow cytometry (FCM). Scratch test and transwell assay were conducted for cell migration and invasion. Orthotopic glioma tumor model in nude mice was established by inoculating tumor cell suspension. Hematoxylin\u2010Eosin (HE) staining was used to observe the growth and invasion of orthotopic glioma tumors. The expression of HOTAIR and cell viability was found to be lowest in the sh\u2010HOTAIR group among the three groups. The sh\u2010HOTAIR group exhibited a higher apoptotic rate and lower number of cell migration compared with the blank and sh\u2010NC groups. Additionally, the speed of wound healing was slower, the migration distance decreased and the survival time of nude mice was extended in the sh\u2010HOTAIR compared to the other groups. Moreover, the sh\u2010HOTAIR group demonstrated reduced lesion sizes and inflammation, no convulsions or hemiplegia and lesser number of satellite metastases. Our findings support that down\u2010regulation of HOTAIR could inhibit cell proliferation, promote cell apoptosis as well as suppress cell invasion and migration in the progression of glioma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26390","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:12:31Z","timestamp":1504167151000},"page":"2278-2287","source":"Crossref","is-referenced-by-count":16,"title":["<i>Retracted<\/i>: Down\u2010regulation of the long noncoding RNA\u2010HOX transcript antisense intergenic RNA inhibits the occurrence and progression of glioma"],"prefix":"10.1002","volume":"119","author":[{"given":"Bin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery People's Hospital of Zhengzhou University Zhengzhou P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-101X","authenticated-orcid":false,"given":"Xing\u2010Yao","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery People's Hospital of Zhengzhou University Zhengzhou P.R. 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