{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:49:41Z","timestamp":1783734581431,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Leishmania, a protozoan parasite that causes leishmaniasis, affects 1\u20102 million people every year worldwide. Leishmaniasis is a vector born disease and characterized by a diverse group of clinical syndromes. Current treatment is limited because of drug resistance, high cost, poor safety, and low efficacy. The urgent need for potent agents against<jats:italic>Leishmania<\/jats:italic>has led to significant advances in the development of novel antileishmanial drugs. \u03b2\u2010galactofuranose (\u03b2\u2010Galf) is an important component of<jats:italic>Leishmanial<\/jats:italic>cell surface matrix and plays a critical role in the pathogenesis of parasite. UDP\u2010galactopyranose mutase (UGM) converts UDP\u2010galactopyranose (UDP\u2010Galp) to UDP\u2010galactofuranose (UDP\u2010Galf) which acts as the precursor for \u03b2\u2010Galf synthesis. Due to its absence in human, this enzyme is selected as the potential target in search of new antileishmanial drugs. Three dimensional protein structure model of<jats:italic>Leishmania major<\/jats:italic>UGM (<jats:italic>Lm<\/jats:italic>UGM) has been homology modeled using<jats:italic>Trypanosoma cruzi<\/jats:italic>UGM (<jats:italic>Tc<\/jats:italic>UGM) as a template. The stereochemistry was validated further. We selected already reported active compounds from PubChem database to target the<jats:italic>Lm<\/jats:italic>UGM. Three compounds (6064500, 44570814, and 6158954) among the top hit occupied the UDP binding site of UGM suggested to work as a possible inhibitor for it. In vitro antileishmanial activity assay was performed with the top ranked inhibitor, 6064500. The 6064500 molecule has inhibited the growth of<jats:italic>Leishmania donovani<\/jats:italic>promastigotes significantly. Further, at similar concentrations it has exhibited significantly lesser toxicity than standard drug miltefosine hydrate in mammalian cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26433","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T12:56:38Z","timestamp":1508763398000},"page":"2653-2665","source":"Crossref","is-referenced-by-count":30,"title":["Identification of novel inhibitors against UDP\u2010galactopyranose mutase to combat leishmaniasis"],"prefix":"10.1002","volume":"119","author":[{"given":"Mohammad","family":"Kashif","sequence":"first","affiliation":[{"name":"Infection and Immunity Lab, Department of Biotechnology Jamia Millia Islamia (A Central University) New Delhi India"},{"name":"Immunobiology Laboratory, Department of Zoology Institute of Science, Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shams","family":"Tabrez","sequence":"additional","affiliation":[{"name":"Infection and Immunity Lab, Department of Biotechnology Jamia Millia Islamia (A Central University) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atahar","family":"Husein","sequence":"additional","affiliation":[{"name":"Infection and Immunity Lab, Department of Biotechnology Jamia Millia Islamia (A Central University) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Arish","sequence":"additional","affiliation":[{"name":"Infection and Immunity Lab, Department of Biotechnology Jamia Millia Islamia (A Central University) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnusamy","family":"Kalaiarasan","sequence":"additional","affiliation":[{"name":"School of Computational and Integrative Sciences Jawaharlal Nehru University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha P.","family":"Manna","sequence":"additional","affiliation":[{"name":"Immunobiology Laboratory, Department of Zoology Institute of Science, Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naidu","family":"Subbarao","sequence":"additional","affiliation":[{"name":"School of Computational and Integrative Sciences Jawaharlal Nehru University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-9790","authenticated-orcid":false,"given":"Yusuf","family":"Akhter","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Central University of Himachal Pradesh Temporary Academic Block Shahpur Kangra (H.P.) 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