{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:04:16Z","timestamp":1784300656871,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The objective of this study is to explore the role of MALAT1 as a molecular indicator in predicting the recurrence, metastasis, and prognosis of gallbladder cancer (GBC) and its effect on the proliferation, invasion, migration, and apoptosis of GBC cells in vitro. GBC tissues and adjacent normal tissues were collected from 102 patients. MALAT1 short hairpin RNA (shRNA) plasmids were first constructed to transfect the GBC\u2010SD cells. Reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) was applied to detect MALAT1 expression. CCK\u20108 assay, flow cytometry, and Transwell assay were applied to testify the cell proliferation, cell cycle, apoptosis, invasion, and migration. A receiver operating characteristic (ROC) curve was used to evaluate the values of MALAT1 in GBC recurrence, metastasis, and prognosis. COX regression analysis was applied to analyze the independent influencing factors of GBC patients\u2019 survival status. ROC curve results showed that the MALAT1 expression could be a predictor of the GBC recurrence, metastasis, and prognosis. According to the COX regression analysis, MALAT1 expression, tumor size, and TNM stage were independent influencing factors of GBC patients\u2019 survival condition. Compared with the GBC\u2010SD cells transfected with empty plasmids, those transfected with MALAT1 shRNA plasmids showed higher apoptosis rates, weakened proliferation, migration, and invasion. In conclusion, our findings demonstrate that lncRNA MALAT1 can be considered as an indicator for evaluating the recurrence, metastasis, and prognosis of GBC patients. We also demonstrate how the overexpression of MALAT1 confers an oncogenic function in GBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26451","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T09:02:48Z","timestamp":1508749368000},"page":"3099-3110","source":"Crossref","is-referenced-by-count":18,"title":["<i>Retracted<\/i>\n                    : Prognostic significance of long non\u2010coding RNA MALAT1 for predicting the recurrence and metastasis of gallbladder cancer and its effect on cell proliferation, migration, invasion, and apoptosis"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-4628","authenticated-orcid":false,"given":"Ke\u2010Ke","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Yinzhou Hospital Affiliated to Medical School of Ningbo University (Yinzhou People's Hospital) Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yinzhou Hospital Affiliated to Medical School of Ningbo University (Yinzhou People's Hospital) Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yinzhou Hospital Affiliated to Medical School of Ningbo University (Yinzhou People's Hospital) Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"221","article-title":"Gallbladder cancer","volume":"3","author":"Rakic M","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"key":"e_1_2_7_3_1","first-page":"99","article-title":"Gallbladder cancer: epidemiology and outcome","volume":"6","author":"Hundal 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