{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:04:19Z","timestamp":1784300659245,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aims to investigate the effects of PPAR\u2010\u03b3 on rats with pregnancy\u2010induced hypertension (PIH) by regulating endothelin receptor (ETR). A total of 60 pregnant Wistar rats were selected, and 50 rats were used to establish endotoxin induced PIH rat models. Rats were equally assigned into PIH\u2010NS, PIH\u20105\u2009mg\/kg RM, PIH\u201010\u2009mg\/kg RM, PIH\u2010100\u2009mg\/kg ETR, and PIH\u2010200\u2009mg\/kg ETR groups, and the rest 10 rats were assigned to a the control group. Reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) and Western blotting were used for determining mRNA and protein expressions of PPAR\u2010\u03b3 and ET\n                      <jats:sub>A<\/jats:sub>\n                      R, respectively. Protein expression of ET\u20101 was detected by immunohistochemistry. Results show that On the 22nd day of pregnancy, compared with the PIH\u2010NS group, SBP decreased in other groups, and platelet concentration increased most significantly in the PIH\u201010\u2009mg\/kg RM and PIH\u2010200\u2009mg\/kg ETR groups. Compared with the control, PIH\u201010\u2009mg\/kg RM and PIH\u2010200\u2009mg\/kg ETR groups, the increase in the expression of ET\u20101 and ET\n                      <jats:sub>A<\/jats:sub>\n                      R was most significant in the PIH\u2010NS group. Compared with the control and PIH\u201010\u2009mg\/kg RM groups, expression of PPAR\u2010\u03b3 was lower in the PIH\u2010NS, PIH\u20105\u2009mg\/kg RM, PIH\u2010100\u2009mg\/kg ETR, and PIH\u2010200\u2009mg\/kg ETR groups. Compared with the PIH\u2010NS, PIH\u2010100\u2009mg\/kg ETR and PIH\u2010200\u2009mg\/kg ETR groups, PPAR\u2010\u03b3 expression was significantly higher in the PIH\u20105\u2009mg\/kg RM group (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Based on our findings, we conclude that PPAR\u2010\u03b3 activation inhibits ETR expression and reduces the effect of ET\u20101 on vascular contraction thereby delaying PIH progression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26454","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T09:28:41Z","timestamp":1508750921000},"page":"3118-3128","source":"Crossref","is-referenced-by-count":2,"title":["Protective effects of PPAR\u2010\u03b3 against pregnancy\u2010induced hypertension by differential ETR expression in rat models"],"prefix":"10.1002","volume":"119","author":[{"given":"Ying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-9726","authenticated-orcid":false,"given":"Qing","family":"Gong","sequence":"additional","affiliation":[{"name":"GMU\u2010GIBH Joint School of Life Sciences Guangzhou Medical University Guangzhou Guangdong Province P.R. 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