{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:59:37Z","timestamp":1789941577651,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Schistosomiasis Control Project in Hubei Province","award":["XF2010-15"],"award-info":[{"award-number":["XF2010-15"]}]},{"name":"Schistosomiasis Control Project in Hubei Province","award":["XF2012-17"],"award-info":[{"award-number":["XF2012-17"]}]},{"name":"Pearl Ocean Liver Fibrosis Basic Research Project","award":["2010-009"],"award-info":[{"award-number":["2010-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Schistosomiasis is one of the world's major public health problems in terms of morbidity and mortality, causing granulomatous inflammation and cumulative fibrosis. This study explored in vivo and vitro effects of miR\u201029b\u20103p in granulomatous liver fibrosis by targeting COL1A1 and COL3A1 in\n                      <jats:italic>Schistosoma japonicum<\/jats:italic>\n                      infection. Thirty male Balb\/c mice were assigned to normal control and model (percutaneous infection of cercariae of\n                      <jats:italic>S. japonicum<\/jats:italic>\n                      ) groups. NIH\u20103T3 mouse embryonic fibroblasts were designated into blank, NC, miR\u201029b\u20103p mimic, TGF\u2010\u03b21, TGF\u2010\u03b21\u2009+\u2009NC, and TGF\u2010\u03b21\u2009+\u2009miR\u201029b\u20103p mimic groups. HE and Masson staining were employed to observe the pathological changes and collagenous fibrosis. The expression of \u03b1\n                      <jats:bold>\u2010<\/jats:bold>\n                      SMA, COL1A1, COL3A1, TIMP\u20101 was determined by immunohistochemistry. The RT\u2010qPCR, Western blotting and immunofluorescence staining were conducted to determine expression of miR\u201029b\u20103p, COL1A1, and COL3A1. CCK\u20108 assay and flow cytometry were performed to evaluate viability and apoptosis. The relative expression of miR\u201029b\u20103p decreased in the model group. The model group showed marked fibrosis in liver tissues. The expression of \u03b1\n                      <jats:bold>\u2010<\/jats:bold>\n                      SMA, COL1A1, COL3A1, TIMP\u20101 was higher in the model group than that in the normal control group. Dual luciferase reporter gene assay revealed that miR\u201029b\u20103p directly targeted COL1A1 and COL3A1. Compared with the blank, NC, TGF\u2010\u03b21 and TGF\u2010\u03b21\u2009+\u2009NC groups, the miR\u201029b\u20103p mimic group exhibited up\u2010regulated expression of miR\u201029b\u20103p and MMP\u20109 but down\u2010regulated expression of TIMP\u20101, HSP47, \u03b1\u2010SMA, COL1A1, and COL3A1; while lower cell viability but higher apoptosis rate showed. It indicated that miR\u201029b\u20103p prevents\n                      <jats:italic>S. japonicum<\/jats:italic>\n                      \u2010induced liver fibrosis by inhibiting COL1A1 and COL3A1.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26475","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T09:36:51Z","timestamp":1509529011000},"page":"3199-3209","source":"Crossref","is-referenced-by-count":65,"title":["<i>Retracted<\/i>\n                    : MicroRNA\u201029b\u20103p prevents\n                    <i>Schistosoma japonicum<\/i>\n                    \u2010induced liver fibrosis by targeting COL1A1 and COL3A1"],"prefix":"10.1002","volume":"119","author":[{"given":"Ran","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan P.R. 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