{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:18:37Z","timestamp":1789935517214,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study aimed to investigate the effect of parathyroid hormone (PTH1\u201034) on osteogenic and adipogenic differentiation of hBMSCs by the regulation of miR\u2010155. A total of 36 adult volunteers were selected in this study. Effects of PTH1\u201034 on the proliferation of hBMSCs and miR\u2010155 expression were investigated using a MTT assay. The hBMSCs were divided into blank, PTH1\u201034, miR\u2010155 mimic, miR\u2010155 mimic negative control (NC), miR\u2010155 inhibitor, miR\u2010155 inhibitor NC, PTH1\u201034\u2009+\u2009miR\u2010155 mimic, PTH1\u201034\u2009+\u2009miR\u2010155 inhibitor, and NPS R\u2010568 groups. Postmenopausal osteoporosis (PMOP) mouse models were established by ovariectomy (OVX) and divided into ten groups. The RT\u2010qPCR and Western blotting assay were carried out to detect the expression of osteogenesis\/adipogenic\u2010related genes and miR\u2010155, and osteogenesis\/adipogenic\u2010related proteins. PTH1\u201034 could promote hBMSCs proliferation and inhibit miR\u2010155 expression in a dose\u2010dependent manner. Compared with the blank control group, expressions of Runx2, and BSP was up\u2010regulated in the PTH1\u201034 and miR\u2010155 inhibitor groups, while expressions of miR\u2010155, PPAR\u2010\u03b3, lipoprotein lipase (LPL), fatty acid binding protein 4 (Fabp4), adiponectin, and CCAAT\/enhancer binding protein \u03b1 (C\/EBP\u03b1) were down\u2010regulated. In the in vivo experiment, compared with the OVX group, the BMD and expressions of Runx2 and BSP was up\u2010regulated in the PTH1\u201034, miR\u2010155 inhibitor, and PTH1\u201034\u2009+\u2009miR\u2010155 inhibitor groups, while expressions of PPAR\u2010\u03b3, LPL, Fabp4, adiponectin, and C\/EBP\u03b1 were down\u2010regulated. The miR\u2010155 mimic and NPS R\u2010568 groups followed opposite trends. PTH1\u201034 could promote the osteogenic differentiation and inhibits adipogenic differentiation of hBMSCs through down\u2010regulating miR\u2010155 in PMOP mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26478","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T09:36:40Z","timestamp":1509529000000},"page":"3220-3235","source":"Crossref","is-referenced-by-count":9,"title":["<i>Retracted<\/i>\n                    : In vivo and in vitro effects of PTH1\u201034 on osteogenic and adipogenic differentiation of human bone marrow\u2010derived mesenchymal stem cells through regulating microRNA\u2010155"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-2646","authenticated-orcid":false,"given":"Huan\u2010Sheng","family":"Han","sequence":"first","affiliation":[{"name":"Special Economic Animal Research Center Harbin Speciality Research Institute Heilongjiang Academy of Land Reclamation Sciences Harbin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology The First Affiliated Hospital of Harbin Medical University Harbin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology The First Affiliated Hospital of Harbin Medical University Harbin P.R. 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