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In this study, a combined strategy was applied to evaluate bone marrow\u2010derived MSCs (BMSCs) homing to the rat model of liver cirrhosis induced by common bile duct ligation (CBDL): (1) pretreatment delivery of resveratrol into the cirrhotic liver, and (2) transplantation of ex vivo BMSC preconditioning with SDF\u20101\u03b1. BMSCs were preconditioned with 10\u2009ng\/\u00b5L SDF\u20101\u03b1 for 1\u2009h and then labeled with the CM\u2010Dil. Cirrhosis was induced by CBDL. Animals received intraperitoneal injection of resveratrol for 7 days, started on day 28 of CBDL post\u2010operative. On day 36 post\u2010operative, 1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> of SDF\u20101\u03b1\u2010preconditioned BMSCs was injected via caudal vein. Animals were sacrificed at 72\u2009h post\u2010cell transplantation. Immunofluorescence and flow cytometry assessments showed that the BMSC+SDF+RV group had an increased rate of homing into the liver, but it had a decreased rate of homing into the lung and spleen, as compared with the other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The BMSC+SDF+RV group showed high protein expression of SIRT1, but low protein expression of p53 in the liver (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 vs other groups). <jats:italic>CXCR4<\/jats:italic> and <jats:italic>matrix metalloproteinase (MMP)\u20109 highly expressed in<\/jats:italic> SDF\u20101\u03b1\u2010preconditioned BMSCs in vitro, and that <jats:italic>AKTs<\/jats:italic> and <jats:italic>CXCL12<\/jats:italic> expressed in injured liver undergoing resveratrol injection. Our findings suggest that reseveratrol pretreatment prior to SDF\u20101\u03b1 preconditioning could be a promising strategy for designing cell\u2010based therapies for liver cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26500","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T15:26:46Z","timestamp":1510414006000},"page":"2939-2950","source":"Crossref","is-referenced-by-count":32,"title":["Resveratrol pretreatment enhanced homing of SDF\u20101\u03b1\u2010preconditioned bone marrow\u2010derived mesenchymal stem cells in a rat model of liver cirrhosis"],"prefix":"10.1002","volume":"119","author":[{"given":"Mehrdad","family":"Hajinejad","sequence":"first","affiliation":[{"name":"Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Pasbakhsh","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Omidi","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Sciences Faculty Tarbiat Modares University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-3465","authenticated-orcid":false,"given":"Keywan","family":"Mortezaee","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Nekoonam","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Yasuj University of Medical Sciences Yasuj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj Ragerdi","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.2109"},{"key":"e_1_2_8_3_1","first-page":"106","article-title":"Retinoic acid as the stimulating factor for differentiation of Wharton's Jelly\u2010Mesenchymal stem cells into hepatocyte\u2010like cells","volume":"7","author":"Mortezaee K","year":"2015","journal-title":"Avicenna J Med Biotechnol"},{"key":"e_1_2_8_4_1","first-page":"207","article-title":"Melatonin pretreatment enhances the homing of bone marrow\u2010derived mesenchymal stem cells following transplantation in a rat model 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