{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:59:47Z","timestamp":1768208387498,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Key Specialty Construction Project of Medical Health System in The Fourth Cycle, Jinshan, Shanghai","award":["2012-26"],"award-info":[{"award-number":["2012-26"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Dysregulated long non\u2010coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development and progression of human cancers. X\u2010inactive specific transcript (XIST), an lncRNA, is known as an oncogene in multiple tumors. However, the roles of XIST and its related miRNAs in nasopharyngeal carcinoma (NPC) are poorly understood. In this study, we found that XIST expression was significantly upregulated in NPC tissues and cell lines. Knockdown of XIST inhibited NPC cell proliferation and invasion and induced apoptosis in vitro, as well as suppressed NPC tumor growth in vivo. Further analysis revealed that XIST and miR\u2010491\u20105p interact with and repress each other. XIST may function as an endogenous miR\u2010491\u20105p sponge to regulate the target gene of miR\u2010491\u20105p. Taken together, these results provide a comprehensive view of the XIST\/miR\u2010491\u20105p axis in human NPC cells and may provide a new therapeutic target for treating NPC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26535","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T12:23:04Z","timestamp":1512735784000},"page":"3936-3944","source":"Crossref","is-referenced-by-count":24,"title":["Knockdown of long non\u2010coding RNA XIST suppresses nasopharyngeal carcinoma progression by activating miR\u2010491\u20105p"],"prefix":"10.1002","volume":"119","author":[{"given":"Qiang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of ENT Jinshan Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of ENT Jinshan Hospital Affiliated to Fudan University Shanghai 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