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The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past 10 years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low 5\u2010year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut, and\/or alcohol, major etiologies. The expression modulations in the identified genes were analyzed in 16 patients comprising oral pre\u2010cancer and cancer histo\u2010pathologies. The genes <jats:italic>SCCA1<\/jats:italic> and <jats:italic>KRT1<\/jats:italic> were found to down regulate while <jats:italic>DNAJC13<\/jats:italic>, <jats:italic>GIPC2<\/jats:italic>, <jats:italic>MRPL17<\/jats:italic>, <jats:italic>IG<\/jats:italic>\u2010<jats:italic>Vreg<\/jats:italic>, <jats:italic>SSFA2<\/jats:italic>, and <jats:italic>UPF0415<\/jats:italic> upregulated in the oral pre\u2010cancer and cancer pathologies, implicating the genes as crucial players in oral carcinogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26554","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T14:26:46Z","timestamp":1513175206000},"page":"5186-5221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study"],"prefix":"10.1002","volume":"119","author":[{"given":"Sapna","family":"Khowal","sequence":"first","affiliation":[{"name":"Department of Biotechnology School of Chemical and Life Sciences Jamia Hamdard, New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar H.","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Genetix Biotech Asia (P) Ltd. 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