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The fundamental role of leptin is to maintain the energy homeostasis with the aid of its counter hormone called ghrelin, known as the \u201chunger hormone.\u201d Small quantities of leptin are also present in various tissues like ovary, placenta, pituitary gland, mammary gland, skeletal muscle, stomach, and lymphoid tissue. Expression of leptin is strongly associated with various inflammatory responses and immune system, and plays crucial role in the pathophysiology of obesity and development of diabetes mellitus (DM) and insulin resistance. The metabolic action of leptin is equally important as that of insulin in the pathophysiology of obesity and DM. Thereby, this review article tends to discuss the diverse and complicated role of leptin in the pathogenesis of DM. Furthermore, this article will highlight the signifying role of leptin as a therapeutic target by indicating the targeted treatment of DM through the appropriate understanding of advanced therapeutic approaches using leptin as a treatment strategy for DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26580","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T14:26:47Z","timestamp":1513175207000},"page":"5016-5027","source":"Crossref","is-referenced-by-count":43,"title":["Leptin: A new therapeutic target for treatment of diabetes mellitus"],"prefix":"10.1002","volume":"119","author":[{"given":"Kanwal","family":"Rehman","sequence":"first","affiliation":[{"name":"Institute of Pharmacy Physiology and Pharmacology University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-5233","authenticated-orcid":false,"given":"Muhammad Sajid Hamid","family":"Akash","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Government College University Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunaira","family":"Alina","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy Physiology and Pharmacology University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0470"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150710145428"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.05.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00270.x"},{"key":"e_1_2_10_7_1","unstructured":"UbeeTJ AdebisiJA.2015. 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