{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:32:13Z","timestamp":1790019133406,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors. The degradation of aggrecan by upregulated ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) is the key event in the development of OA. ADAMTS\u20104 contributes to aggrecan degradation in human OA. Cysteine\u2010rich angiogenic inducer 61 (Cyr61), which is associated with diseases related to chronic inflammation, is found in articular cartilage from patients with osteoarthritis and appears to suppress ADAMTS\u20104 activity, possibly leading to chondrocyte cloning. Herein, we first revealed that Cyr61 and ADAMTS\u20104 protein levels were remarkably increased in OA cartilage tissues and OA chondrocytes, and verified Cyr61 regulation of ADAMTS\u20104 in normal and OA chondrocyte. Further, we revealed that Cyr61 could promote OA chondrocyte proliferation through inhibiting ADAMTS\u20104. Overproduction of inflammatory cytokines plays a vital role in the pathological development of OA; herein, we demonstrated that IL\u20101\u03b2 inhibited Cyr61, while promoted ADAMTS\u20104 expression. By using online tools and luciferase assays, we confirmed that miR\u201034a, a regulatory miRNA of chondrocyte proliferation, could directly bind to the 3\u2032\u2010UTR of Cyr61 to inhibit its expression; further, IL\u20101\u03b2 regulated Cyr61 and ADAMTS\u20104 expression through miR\u201034a. In OA cartilage tissues, miR\u201034a, and IL\u20101\u03b2 mRNA expression was up\u2010regulated and positively correlated; miR\u201034a and Cyr61 mRNA was positively correlated, further indicating that suppressing miR\u201034a expression might rescue IL\u20101\u03b2\u2010induced Cyr61 suppression, and promote OA chondrocyte proliferation. Taken together, we provided novel experimental basis for rescuing OA chondrocyte proliferation through miR\u201034a\/Cyr61 axis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26600","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T14:22:41Z","timestamp":1513174961000},"page":"7959-7970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["IL\u20101\u03b2\u2010induced miR\u201034a up\u2010regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS\u20104"],"prefix":"10.1002","volume":"119","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-9075","authenticated-orcid":false,"given":"Jiangdong","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pain The Second Affiliated Hospital of Nanhua University Hengyang Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan P.R. 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