{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:04:02Z","timestamp":1772751842424,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The study intends to investigate the effects of long non\u2010coding RNA HOST2 (lncRNA HOST2) on cell migration and invasion by regulating microRNA let\u20107b (let\u20107b) in breast cancer. Breast cancer and adjacent normal tissues were collected from 98 patients with breast cancer. Breast cancer MCF\u20107 cells were divided into the blank, negative control (NC), pcDNA3\u2010Mock, siHOST2, let\u20107b inhibitor, pcDNA3\u2010HOST2, let\u20107b mimic, pcDNA3\u2010HOST2\u2009+\u2009let\u20107b mimic, and siHOST2\u2009+\u2009let\u20107b inhibitor groups. RT\u2010qPCR was used to detect the mRNA expressions of HOST2, let\u20107b, and c\u2010Myc. Western blotting was conducted to measure the c\u2010Myc expression. Scratch test and Transwell assay were applied to detect the cell motility, migration, and invasion. Xenograft tumor in nude mice was performed to evaluate the effect of different transfection on the tumor growth. Compared with adjacent normal tissues, HOST2 expression was higher but let\u20107b expression lower in breast cancer tissues. HOST2 expression in breast cancer cells was remarkably increased compared with that in the normal breast epithelial MCF\u201010A cells. In MCF\u20107 cells, in comparison with the blank and NC groups, expressions of HOST2 and c\u2010Myc were reduced, but let\u20107b expression was remarkably elevated in the siHOST2 and let\u20107b mimic groups; the let\u20107b inhibitor group exhibited higher expressions of HOST2 and c\u2010Myc but lower let\u20107b expression. Overexpression of HOST2 could promote cell motility, migration and invasion, thus enhancing the growth of breast cancer tumor. By inhibiting HOST2, opposite trends were found. LncRNA HOST2 promotes cell migration and invasion by inhibiting let\u20107b in breast cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26606","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T14:05:58Z","timestamp":1513173958000},"page":"4570-4580","source":"Crossref","is-referenced-by-count":22,"title":["<i>Retracted<\/i>: Effects of long non\u2010coding RNA HOST2 on cell migration and invasion by regulating MicroRNA let\u20107b in breast cancer"],"prefix":"10.1002","volume":"119","author":[{"given":"Peng\u2010Wei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou P.R. 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