{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:57:03Z","timestamp":1781708223057,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16DZ1930102"],"award-info":[{"award-number":["16DZ1930102"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The study explores whether miR\u2010139\u20105p targeting LPAR4 affects epithelial\u2010mesenchymal transition (EMT) and fibrosis in post\u2010menopausal women with interstitial cystitis (IC) via the PI3K\/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed by HE, Masson and Picrosirius red staining. LPAR4 positive expression rate were determined by IHC. ELISA was performed to detect the levels of IL\u20106, IL\u20108, IL\u201010, and TNF\u2010\u03b1. Rat IC models were randomized into seven different groups. miR\u2010139\u20105p, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, P13K, Akt, E\u2010cadherin, N\u2010cadherin, Vimentin, TGF\u2010\u03b21, and CTGF expression were determined by RT\u2010qPCR and Western blotting. Dual luciferase reporter gene assay verified that LPAR4 is a target gene of miR\u2010139\u20105p. Fibrosis was a pathological manifestation of IC. The IC group showed higher LPAR4, PI3K, Akt, p\u2010PI3K, p\u2010Akt, N\u2010cadherin, Vimentin, TGF\u2010\u03b21, and CTGF expression but lower miR\u2010139\u20105p and E\u2010cadherin expression than the normal group. The levels of IL\u20106, IL\u20108, IL\u201010, and TNF\u2010\u03b1 expression decreased while HB\u2010EGF increased in the IC group in comparison of the normal group. Compared with the blank and NC groups, E\u2010cadherin expression was increased in the miR\u2010139\u20105p mimic and siRNA\u2010LPAR4 groups, while LPAR4, PI3K, Akt, p\u2010P13K, p\u2010Akt, N\u2010cadherin, Vimentin, TGF\u2010\u03b21, and CTGF expression were decreased. An opposite trend was found in the miR\u2010139\u20105p inhibitor group. The miR\u2010139\u20105p decreased in the miR\u2010139\u20105p inhibitor\u2009+\u2009siRNA\u2010LPAR4 and miR\u2010139\u20105p inhibitor\u2009+\u2009wortmannin groups. Conclusively, miR\u2010139\u20105p targeting LPAR4 inhibits EMT and fibrosis in post\u2010menopausal IC women through the PI3K\/Akt signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26610","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T14:34:18Z","timestamp":1513262058000},"page":"6429-6441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>Retracted<\/i>: Microrna\u2010139\u20105p inhibits epithelial\u2010mesenchymal transition and fibrosis in post\u2010menopausal women with interstitial cystitis by targeting LPAR4 via the PI3K\/Akt signaling pathway"],"prefix":"10.1002","volume":"119","author":[{"given":"Chen","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Urology, South Campus, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai P. R. 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