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Several factors are likely involved in its onset. The genetic susceptibility of IgE\u2010responsiveness likely caused by polymorphism(s) in high affinity receptor for IgE (Fc\u025bR1\u03b1) gene can help in understanding the pathophysiology of CRS with nasal polyposis (CRSwNP). A population\u2010based case\u2010control association analysis was conducted to assess the risk of CRSwNP conferred by single nucleotide polymorphisms (SNPs) in Fc\u025bR1\u03b1 gene in a North Indian cohort. Two promoter and three exonic regions of Fc\u025bR1\u03b1 gene were amplified and sequenced to investigate five SNPs: rs2427827, rs2251746, rs2298804, rs2298805, and rs2269718. BLAST analysis and subsequent multiple alignments, with known sequences available in the NCBI database, were performed. Total serum IgE and Fc\u025bR1\u03b1 antibody levels were estimated. Patient IgE level of 461.22\u2009\u00b1\u2009436.43 in comparison to 83.62\u2009\u00b1\u200958.043 IU\/mL in controls (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.0001), and Fc\u025bR1\u03b1 antibody level of 292.38\u2009\u00b1\u2009115.27 in comparison to 160.56\u2009\u00b1\u2009105.9 in controls (<jats:italic>P\u2009&lt;\u2009<\/jats:italic>0.0001), depicts their highly significant associations with CRSwNP disease. However, no SNP showed evidence of association with CRSwNP; although relatively higher Odds ratios were observed with rs2427827, rs2251746, and rs2298804. Patient stratification revealed a significant association (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05) of rs2427827 SNP with high IgE level CRSwNP patients. Nonetheless, we found no SNP associated with low serum IgE level patients. SNP (rs2427827) in the Fc\u025bR1\u03b1 gene region and high IgE levels may confer susceptibility to CRSwNP in north Indian population. However, further studies including larger sample size, gene\u2010gene, and gene\u2010environment interactions are required for its elucidation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26619","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T21:37:20Z","timestamp":1513460240000},"page":"4142-4149","source":"Crossref","is-referenced-by-count":10,"title":["Fc\u025bR1\u03b1 gene polymorphism shows association with high IgE and anti\u2010Fc\u025bR1\u03b1 in Chronic Rhinosinusitis with Nasal Polyposis"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-8701","authenticated-orcid":false,"given":"Sajad A.","family":"Dar","sequence":"first","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"},{"name":"Research and Scientific Studies Unit College of Nursing &amp; Allied Health Sciences University of Jazan Jazan 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