{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:05:59Z","timestamp":1767135959947,"version":"build-2238731810"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study determines whether cullin 4B (CUL4B) promotes pancreatic cancer (PC) metastasis by inducing epithelial\u2010mesenchymal transition (EMT) via the Wnt\/\u03b2\u2010catenin signaling pathway. A total of 64 PC patients were enrolled in this study. Human PC cell lines were distributed into blank, negative control, shCUL4B, PLOC, PLOC\u2010CUL4B, and PLOC\u2010CUL4B\u2009+\u2009siRNA\u2010\u03b2\u2010catenin groups. The expressions of CUL4B, Wnt\/\u03b2\u2010catenin signaling pathway\u2010related proteins, and EMT\u2010related proteins were determined using RT\u2010qPCR and Western blotting. The positive expressions of CUL4B and \u03b2\u2010catenin protein in tissues were detected by immunohistochemistry. MTT assay and flow cytometry was performed for cell proliferation and cell cycle, scratch test, and transwell assay for cell migration and invasion ability. CUL4B and \u03b2\u2010catenin were expressed at a higher level in PC tissues than in paracancerous tissues though paracancerous tissues had higher expressions of CUL4B and \u03b2\u2010catenin than normal tissues. The PLOC\u2010CUL4B group showed increased CUL4B, Wnt, \u03b2\u2010catenin, LEF\u20101, c\u2010Jun, Cyclin D1, N\u2010cadherin, Vimentin, Snail, and ZEB1 expression; decreased E\u2010cadherin expression; accelerated cell proliferation; increased S\u2010phase cell percentages; increased cell migration ability; more liver metastases; and enlarged tumor than the PLOC and PLOC\u2010CUL4B\u2009+\u2009siRNA\u2010\u03b2\u2010catenin groups. The shCUL4B group showed decreased CUL4B, Wnt, \u03b2\u2010catenin, LEF\u20101, c\u2010Jun, Cyclin D1, N\u2010cadherin, Vimentin, Snail, and ZEB1 expression; increased E\u2010cadherin expression; decelerated cell proliferation; decreased S\u2010phase cell percentages; reduced cell migration ability; less liver metastases; and decreased tumor weight than the blank and negative control groups. We demonstrate that CUL4B promotes PC metastasis by inducing EMT via the Wnt\/\u03b2\u2010catenin signaling pathway. Therefore, CUL4B might be the clinical target for treating PC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26643","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T06:13:25Z","timestamp":1514096005000},"page":"5308-5323","source":"Crossref","is-referenced-by-count":18,"title":["<i>Retracted<\/i>\n                    : CUL4B promotes metastasis and proliferation in pancreatic cancer cells by inducing epithelial\u2010mesenchymal transition via the Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9860","authenticated-orcid":false,"given":"Yue\u2010Ming","family":"He","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Bililary Surgery Zhongnan Hospital of Wuhan University Wuhan P.R. 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