{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:37:11Z","timestamp":1790563031901,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Berberine (BBR) is an isoquinoline alkaloid derived from various medicinal herbs. Previous studies have suggested that BBR exerts antimicrobial, antitumor, and antidiabetic effects and can be used to treat\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      \u2010induced chronic gastritis. However, the exact mechanism by which BBR inhibits\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection is not fully understood. We investigated the anti\u2010inflammatory properties and potential mechanism of BBR in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010infected mice with chronic gastritis. We found that BBR can suppress the expression of pro\u2010inflammatory genes IL\u20106, TGF\u2010\u03b2, and IL\u20101\u03b2 and upregulate anti\u2010inflammatory gene IL\u201010 expression in the mucosa and RAW 264.7 macrophages. Exposure to BBR also reduced the expression and accumulation of IL\u201017 in the mucosa and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells activated by anti\u2010CD3 and anti\u2010CD28, and it decreased the frequency of IL\u201017\u2010producing CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells. B cell\u2010activating factor (BAFF) production was inhibited by BBR and by cultured dendritic and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells. Furthermore, we demonstrated that BAFF can trigger the Th17 response by promoting the production of pro\u2010Th17 cytokines IL\u20106, TGF\u2010\u03b2, and IL\u20101\u03b2, which are strongly associated with the anti\u2010inflammatory role of BBR in chronic gastritis caused by\n                      <jats:italic>H. pylori<\/jats:italic>\n                      . In conclusion, we determined that BBR has anti\u2010inflammatory effects on\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010induced chronic gastritis by attenuating the BAFF\u2010triggered Th17 response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26681","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T09:21:04Z","timestamp":1516267264000},"page":"5373-5381","source":"Crossref","is-referenced-by-count":42,"title":["Berberine demonstrates anti\u2010inflammatory properties in\n                    <i>Helicobacter pylori<\/i>\n                    \u2010infected mice with chronic gastritis by attenuating the Th17 response triggered by the B cell\u2010activating factor"],"prefix":"10.1002","volume":"119","author":[{"given":"Xiuxia","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Liver Spleen and Stomach Henan Province Hospital of TCM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-4959","authenticated-orcid":false,"given":"Xian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Spleen and Stomach Henan Province Hospital of TCM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqin","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Liver Spleen and Stomach Henan Province Hospital of TCM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Liver Spleen and Stomach Henan Province Hospital of TCM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12165"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Epidemiology of Helicobacter pylori Infection","volume":"19","author":"Queiroz DMM","year":"2014","journal-title":"Leber Magen Darm"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-013-1863-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8050142"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1908"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901115"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300524"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.09.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90599.2008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00211.2007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i14.4225"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.76"},{"key":"e_1_2_7_15_1","unstructured":"G.Wei Berberine auxiliary treatment of type 2 diabetes mellitus and helicobacter pylori infection the clinical curative effect and security of the peptic ulcer. 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