{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:31:55Z","timestamp":1787243515818,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["11546"],"award-info":[{"award-number":["11546"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Acute liver failure (ALF) is a lethal disease with limited life\u2010saving therapy. Because lack of whole organ donors for liver transplantation, a substitute treatment strategy is needed for these patients. Preclinical and clinical findings have proved that treatment with mesenchymal stem cells (MSCs) is beneficial for recovery from ALF. In this approach, however, the appropriate sources of these cells are unclear. In the present study, we investigated and compared the therapeutic potentials of bone marrow\u2010mesenchymal stem cells (BM\u2010MSC) with those of adipose tissue (AT\u2010MSC) in carbon tetrachloride (CCL4)\u2010induced acute liver failure in mice. Murine BM\u2010 and AT\u2010MSCs obtained from normal mice were cultured and labelled. The cells were transplanted to CCL4\u2010induced ALF mice models intravenously. After cell transplantation, blood samples and liver tissues were collected daily for 72\u2009h to analyze liver enzymes and liver histopathology, respectively. We found that survival rate of AT\u2010MSC transplanted (AT\u2010TR) mice was significantly higher than that of control (ALF) group. Liver histopathology was superior in the AT\u2010TR mice, but not significantly, compared to that in BM\u2010MSC transplanted (BM\u2010TR) ones. Furthermore, in the AT\u2010TR mice the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), in some time points were significantly less than those of BM\u2010TR. Taken together, these data suggest that in comparison to BM\u2010MSC, AT\u2010MSCs is an appropriate choice for cell therapy in the case of acute liver failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.26772","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:26:08Z","timestamp":1521984368000},"page":"5834-5842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Bone marrow or adipose tissue mesenchymal stem cells: Comparison of the therapeutic potentials in mice model of acute liver failure"],"prefix":"10.1002","volume":"119","author":[{"given":"Hossein","family":"Zare","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad M.","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Surgery and Radiology Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Saheli","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-6214","authenticated-orcid":false,"given":"Abbas","family":"Piryaei","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44043"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X662462"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0572"},{"key":"e_1_2_6_8_1","first-page":"103","article-title":"Differentiation of bone marrow\u2010derived mesenchymal stem cells into hepatocyte\u2010like cells on nanofibers and their transplantation into a carbon tetrachloride\u2010induced liver fibrosis 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