{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:59:33Z","timestamp":1758891573285,"version":"3.40.4"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Trimeresurus malabaricus<\/jats:italic> is a venomous pit viper species endemic to southwestern part of India. In earlier reports, we have shown that envenomation by <jats:italic>T. malabaricus<\/jats:italic> venom leading to strong local tissue damage but the mechanism of action is not clearly revealed. Local tissue damage affected by <jats:italic>T. malabaricus<\/jats:italic> venom is of great importance since the poison has serious systemic effects including death in the case of multiple attacks. The present study details the major manifestations of <jats:italic>T. malabaricus<\/jats:italic> venom and the induction of local tissue damage, which suggests that most toxins are present in the form of hydrolytic enzymes. Hydrolytic activity of the enzymes was measured and the data indicated that protease and phospholipase A<jats:sub>2<\/jats:sub> activity was high which is responsible for local tissue damage. Furthermore, the role of hydrolytic enzymes in the induction of pathological events such as hemorrhage, edema, myotoxicity, and blood coagulation examination were assessed through animal models.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26782","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T11:12:38Z","timestamp":1520853158000},"page":"5904-5912","source":"Crossref","is-referenced-by-count":8,"title":["Biochemical and pharmacological characterization of <i>Trimersurus malabaricus<\/i> snake venom"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-8384","authenticated-orcid":false,"given":"Raghavendra","family":"Gowda","sequence":"first","affiliation":[{"name":"Department of Pharmacology Penn State College of Medicine Penn State University Hershey 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