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Evidence shows that long non\u2010coding RNAs (lncRNA) play important roles in HSCR. The MIR31 host gene (MIR31HG), also known as Loc554202, is a long non\u2010coding RNA (lncRNA), which acts as the host gene of (microRNA) miR\u201031 and miR\u201031*. There have been no studies regarding its function in early developmental defects during pregnancy, and its downstream genetic receptors. We report that downregulation of MIR31HG inhibited migration and proliferation in 293T and SH\u2010SY5Y cell lines, by suppressing miR\u201031 and miR\u201031*. Moreover, the downregulation of miR\u201031 and miR\u201031* enhanced inter\u2010\u03b1\u2010trypsin inhibitor heavy chain 5 (ITIH5) and the phosphatidylinositol\u20104, 5\u2010bisphosphate 3\u2010kinase catalytic gamma subunit (PIK3CG), respectively with reductions of cell migration and proliferation in 293T and SH\u2010SY5Y cell lines. In addition, synergistic actions were observed between miR\u201031 and miR\u201031* in cell migration and proliferation. Our results demonstrated that the MIR31HG\u2010miR\u201031\/31*\u2010ITIH5\/PIK3CG pathway plays a role in the pathogenesis of HSCR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26830","type":"journal-article","created":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T06:38:36Z","timestamp":1523083116000},"page":"8195-8203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Aberrant expression of LncRNA\u2010MIR31HG regulates cell migration and proliferation by affecting miR\u201031 and miR\u201031* in Hirschsprung's disease"],"prefix":"10.1002","volume":"119","author":[{"given":"Peng","family":"Cai","sequence":"first","affiliation":[{"name":"Children's Hospital of Soochow University Suzhou P.R. 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