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The main drawbacks of MSC therapy are the lack of specific homing after systemic infusion and early death of injected cells because of the injury micro\u2010environment. We pretreated bone mesenchymal stem cells (BMSCs) with erythropoietin (EPO) to investigate their positive effect on cyclosporine A (CsA)\u2010induced nephrotoxicity. BMSCs were incubated with different concentrations of EPO (10, 100, 500, and 1000\u2009IU\/mL) for 24 and 48\u2009h, and their proliferation rate, cytoskeletal morphology, migration ability, and the expression of CXCR4 were evaluated to determine the optimal pretreatment conditions. To investigate the therapeutic effects of BMSCs pretreated with EPO in CsA\u2010induced nephrotoxicity, we established CsA\u2010induced in vitro and in vivo toxicity models. In our in vitro study, preconditioning of BMSCs with 500\u2009IU\/mL EPO for 48\u2009h induced a marked increase in their proliferation rate, cytoskeletal rearrangement, migration in the scrape\u2010healing assay, and migration toward injured HK2 cells. In vivo, EPO\u2010BMSCs showed higher ability to improve renal function than BMSCs, and in CsA\u2010induced rats treated with EPO\u2010BMSCs, interstitial lymphocyte infiltration, tubular swelling, necrosis, and interstitial fibrosis decreased. We demonstrated that pretreatment with 500\u2009IU\/mL EPO before infusion markedly increased the homing ability of BMSCs, and obviously ameliorate CsA\u2010induced nephrotoxicity in rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26833","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T11:10:43Z","timestamp":1529665843000},"page":"8220-8232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bone mesenchymal stem cells pretreated with erythropoietin enhance the effect to ameliorate cyclosporine A\u2010induced nephrotoxicity in rats"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-3961","authenticated-orcid":false,"given":"Song","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Organ Transplantation, Zhujiang Hospital Southern Medical University Guangzhou Guangdong Province 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