{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:01Z","timestamp":1791919501993,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Accumulating evidence has indicated that MEG3 can serve as a tumor suppressive lncRNA in various tumors. It is aberrantly expressed in multiple cancers. However, the biological roles of MEG3 in melanoma are poorly understood. Therefore, in our study, we concentrated on the biological mechanism of MEG3 in melanoma progression. First, we observed that MEG3 was obviously decreased in melanoma cells including A375, SK\u2010MEL\u20101, B16, and A2058 cells compared to human epidermal melanocytes HEMa\u2010LP. MEG3 was restored by transfecting LV\u2010MEG3 in to A375 and A2058 cells. Subsequently, we found that overexpression of MEG3 was able to inhibit cell proliferation and colony formation capacity. Meanwhile, melanoma cell apoptosis was induced by up\u2010regulation of MEG3. Overexpression of MEG3 greatly repressed melanoma cell migration and invasion ability. In addition, Wnt signaling pathway has been identified in the progression of various cancers. Here, in our study, it was indicated that Wnt signaling was highly activated in melanoma cells with \u03b2\u2010catenin expression significantly increased and GSK\u20103\u03b2 decreased. Interestingly, MEG restoration strongly inactivated Wnt signaling pathway by reducing \u03b2\u2010catenin and CyclinD1, elevating GSK\u20103\u03b2 levels in vitro. Finally, in vivo experiments were carried out to confirm the inhibitory roles of MEG3 in vivo. Taken these together, we suggested that MEG3 can inhibit melanoma development through blocking Wnt signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.27061","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T12:27:00Z","timestamp":1526905620000},"page":"7498-7505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["LncRNA MEG3 repressed malignant melanoma progression via inactivating Wnt signaling pathway"],"prefix":"10.1002","volume":"119","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Center Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Center Hospital of Wuhan Tongji Medical College Huazhong 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