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The aim of our study is to investigate the expression of microRNA\u2010132 (miR\u2010132) and its effect on cardiocyte proliferation, apoptosis, and cardiac fibrosis by binding to phosphatase and tensin homolog (PTEN) through the phosphateidylinositol 3\u2010kinase (PI3K)\/protein kinase (Akt) signal transduction pathway in DCM rats. DCM rat models induced by doxorubicin were established and confirmed by an ultrasonic cardiogram. Epithelial cells were treated with inhibitors, activators, and small interfering RNAs to identify the mechanisms by which miR\u2010132 controls cardiocyte activity and cardiac fibrosis. Angiotensin II (Ang II) and aldosterone (ALD) expressions were detected by an enzyme\u2010linked immunosorbent assay. The relationship between PTEN and miR\u2010132 was verified by a dual\u2010luciferase reporter assay. Cell proliferation and apoptosis were tested by the MTT assay and flow cytometry. PTEN was determined to be the target gene of miR\u2010132. Rat models of DCM exhibited a lower level of miR\u2010132, PI3K, Akt, B\u2010cell lymphoma 2, collagen I, and collagen III, but a higher level of PTEN, Bcl\u20102\u2013associated X protein, and proliferating cell nuclear antigen as well as inflammatory response (Ang II and ALD), accompanied by declined cardiocyte proliferation and elevated apoptosis and cardiac fibrosis. Upregulated miR\u2010132 or silenced PTEN activated the PI3K\/Akt pathway, thus facilitating cardiocyte proliferation and repressing cardiocyte apoptosis and cardiac fibrosis, as well as inflammatory responses. Downregulated miR\u2010132 reversed this tendency. These findings indicate that miR\u2010132 activates the PI3K\/Akt pathway by inhibiting PTEN expression, thus facilitating cardiocyte proliferation and inhibiting apoptosis and cardiac fibrosis in DCM rats.<\/jats:p>","DOI":"10.1002\/jcb.27081","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T04:22:59Z","timestamp":1537071779000},"page":"1232-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Retracted<\/i>: Upregulated microRNA\u2010132 rescues cardiac fibrosis and restores cardiocyte proliferation in dilated cardiomyopathy through the phosphatase and tensin homolog\u2013mediated PI3K\/Akt signal transduction pathway"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-1534","authenticated-orcid":false,"given":"Chen\u2010Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Gongli Hospital 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