{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:48:37Z","timestamp":1781070517115,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFC860"],"award-info":[{"award-number":["2017CFC860"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNAs) are recognized as significant regulators of neuropathic pain. Moreover, neuroinflammation can contribute a lot to the progression of neuropathic pain. MiR\u201028\u20105p has been reported to be involved in many pathological diseases. However, little is known about the function of miR\u201028\u20105p in neuropathic pain development. Our current study was designed to investigate the biological roles of miR\u201028\u20105p in neuropathic pain in a rat model established by chronic sciatic nerve injury (CCI). Here, we observed that miR\u201028\u20105p was decreased in CCI rats. MiR\u201028\u20105p overexpression was able to alleviate neuropathic pain behaviors including mechanical and thermal hyperalgesia. Meanwhile, inflammation\u2010correlated biomarkers such as Cyclooxygenase 2 (Cox\u20102), interleukin\u20106 (IL\u20106), and IL\u20101\u03b2 were greatly promoted in CCI rats and they were inhibited by miR\u201028\u20105p upregulation. In addition, zinc finger E\u2010box\u2010binding homeobox 1 (Zeb1) is a kind of transcription factor that is involved in various diseases. Here, in our study, Zeb1 was predicted as a downstream target of miR\u201028\u20105p. miR\u201028\u20105p can bind with the 3\u2032\u2010untranslated region of Zeb1, which was validated by carrying out dual\u2010luciferase reporter assay. Moreover, we found that Zeb1 was significantly increased in CCI rats and miR\u201028\u20105p can modulate Zeb1 expression negatively. Theoverexpression of Zeb1 can disturb neuropathic pain development, which was repressed by the increase of miR\u201028\u20105p by upregulating Cox\u20102, IL\u20106, and IL\u20101\u03b2 levels. By taking all of these together, it was indicated in our study that miR\u201028\u20105p can reduce neuropathic pain progression by targeting Zeb1 in vivo. Our data implied that miR\u201028\u20105p\/Zeb1 axis can be a novel therapeutic target for neuropathic pain treatment.<\/jats:p>","DOI":"10.1002\/jcb.27096","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T08:29:37Z","timestamp":1532939377000},"page":"8555-8563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["MiR\u201028\u20105p relieves neuropathic pain by targeting Zeb1 in CCI rat models"],"prefix":"10.1002","volume":"119","author":[{"given":"Yongfen","family":"Bao","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Hubei University of Science and Technology Xianning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Hubei University of Science and Technology Xianning 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