{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:56:21Z","timestamp":1775159781222,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) is a severe T cell\u2013mediated disorder of the mucosa, which causes chronic inflammation. Forkhead box P3 (Foxp3) regulates the immune response and plays an important role in immunological diseases. The current study aimed to determine the role of Foxp3 and microRNA (miR)\u2010146a in OLP. Western blot analysis and a quantitative real\u2010time polymerase chain reaction assay showed that the expression of Foxp3 and miR\u2010146a was upregulated in OLP tissues and in lipopolysaccharide (LPS)\u2010incubated HaCaT cells, compared with controls. Foxp3 inhibition significantly decreased miR\u2010146a expression, ameliorated LPS stimulation by decreased cell proliferation, and apoptosis in LPS\u2010incubated HaCaT cells as compared with the LPS group. Cotransfection of Foxp3 small interfering RNA and miR\u2010146a mimics elevated cell proliferation and apoptosis compared with the Foxp3 small interfering RNA group. In addition, miR\u2010146a overexpression upregulated, whereas miR\u2010146a inhibition downregulated, the proliferation and apoptosis of LPS\u2010incubated HaCaT cells. The target gene of miR\u2010\u2013146a, tumor necrosis factor receptor\u2013associated factor 6 (TRAF6), was predicted by bioinformatics software and identified by the luciferase reporter assay. Furthermore, Foxp3\/miR\u2010146a elevated T regulatory cells and regulated TRAF6 expression in CD4<jats:sup>+<\/jats:sup> T cells that were isolated from peripheral blood of patients with OLP. In conclusion, our study suggests that Foxp3 and miR\u2010146a regulate the progression of OLP by negatively regulating TRAF6, which may provide a promising therapeutic target for OLP treatment.<\/jats:p>","DOI":"10.1002\/jcb.27139","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T11:54:09Z","timestamp":1534766049000},"page":"8862-8871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["RETRACTED: Forkhead box p3 controls progression of oral lichen planus by regulating microRNA\u2010146a"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-6219","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20174964"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12243"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2190-3"},{"key":"e_1_2_8_1_5_1","first-page":"438","article-title":"Correlation of Treg and IL\u201015 expression in the peripheral blood of patients with oral lichen planus","volume":"25","author":"Wang CJ","year":"2016","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0017"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706356114"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.75"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0027"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-017-0362-8"},{"key":"e_1_2_8_1_11_1","first-page":"249","article-title":"MicroRNA in immune regulation","volume":"410","author":"Wu CJ","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2091-5"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.043"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2108"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12197"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172821"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.07.045"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma10070843"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1429-3"},{"key":"e_1_2_8_1_20_1","first-page":"472","article-title":"Expressions of RORgammaT; 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