{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:56:50Z","timestamp":1775581010856,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070691"],"award-info":[{"award-number":["81070691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteolysis is a serious complication of several chronic inflammatory diseases and is closely associated with a local chronic inflammatory reaction with a variety of causes. However, similarities exist in the mechanisms of their pathological processes. Inflammatory factors and oxidative stress\u2013induced nuclear factor \u03baB (NF\u2010\u03baB) and mitogen\u2010activated protein kinases (MAPKs) signaling pathways play a center role in bone erosion. Dihydromyricetin (DMY) is a natural compound with anti\u2010inflammatory and antioxidative effect, which are commonly used in chronic pharyngitis and alcohol use disorders. In the current study, we identified that DMY attenuated lipopolysaccharide (LPS)\u2013induced oxidative stress through inhibiting the production of reactive oxygen species (ROS) and nitric oxide (NO), downregulated COX\u20102 and iNOS, and promoted the activity of the antioxidative system by activating superoxide dismutase (SOD) and Nrf2\/HO\u20101 pathway. To further investigate the underlying mechanism, we found that DMY inhibits osteoclast (OC) differentiation and bone resorption activity through blocking the RANKL\u2010induced activation of the NF\u2010\u03baB and MAPKs signaling pathways and then downregulated c\u2010Fos and NFATc1, which is essential for OC differentiation. Furthermore, DMY inhibited LPS\u2010induced osteolysis in vivo. Collectively, these results indicate that DMY might be a promising prophylactic antiosteoclastic\/resorptive agent in preventing or treating bone lysis diseases.<\/jats:p>","DOI":"10.1002\/jcb.27154","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T06:37:06Z","timestamp":1533623826000},"page":"8981-8995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["RETRACTED: (2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS\u2010induced oxidative stress and NF\u2010\u03baB and MAPKs pathways activating"],"prefix":"10.1002","volume":"119","author":[{"given":"Xuejun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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