{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:26:34Z","timestamp":1770906394338,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long noncoding RNAs play essential roles in cancer development and progression. Here, we tried to investigate the role of GIHCG in the progression and metastasis of tongue squamous cell carcinoma (TSCC). In our study, we showed that that the expression level of GIHCG was upregulated in TSCC tissues and cell lines. In addition, we indicated that high GIHCG expression was positively associated with poor overall survival. Moreover, ectopic expression of GIHCG enhanced TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG inhibited the miR\u2010429 expression in TSCC cells. We demonstrated that the expression level of miR\u2010429 was lower in TSCC tissues and cell lines. Low miR\u2010429 expression was positively associated with poor overall survival. We then determined the correlation between miR\u2010429 and GIHCG expression levels. A statistically significantly inverse correlation was observed between miR\u2010429 and GIHCG expression levels in TSCC tissues. In addition, overexpression of miR\u2010429 suppressed the TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG promoted TSCC cell cycle, proliferation, and migration through regulating miR\u2010429 expression. These results suggested that GIHCG increased TSCC progression through negative modulation of miR\u2010429. Our results suggested that GIHCG\/miR\u2010429 might play a vital role in TSCC progression.<\/jats:p>","DOI":"10.1002\/jcb.27164","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T20:11:41Z","timestamp":1530216701000},"page":"9064-9071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Long noncoding RNA GIHCG enhanced tongue squamous cell carcinoma progression through regulating miR\u2010429"],"prefix":"10.1002","volume":"119","author":[{"given":"Long","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Periodontology Jinan Stomatological Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endodontics Jinan Stomatological Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuode","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endodontics Jinan Stomatological Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lande","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Periodontology Jinan Stomatological Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-9876","authenticated-orcid":false,"given":"Zhibin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Jinan Stomatological Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1477-3163.104007"},{"key":"e_1_2_5_1_3_1","first-page":"61","article-title":"miRNA analysis of formalin\u2010fixed squamous cell carcinomas of the tongue is affected by age of the samples","volume":"38","author":"Rentoft M","year":"2011","journal-title":"Int J Oncol"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0666"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(13)60130-3"},{"key":"e_1_2_5_1_6_1","first-page":"675","article-title":"Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells","volume":"6","author":"Yan B","year":"2012","journal-title":"Mol Med Rep"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12499"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3648"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-1976-8"},{"key":"e_1_2_5_1_10_1","first-page":"2957","article-title":"miR\u2010219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI","volume":"7","author":"Song KB","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_5_1_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3053"},{"key":"e_1_2_5_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.051"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28667"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0915-3"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12140"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12312"},{"key":"e_1_2_5_1_17_1","first-page":"3522","article-title":"Long non\u2010coding RNA CASC2 suppresses the proliferation of gastric cancer cells by regulating the MAPK signaling pathway","volume":"8","author":"Li P","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_18_1","first-page":"4095","article-title":"Long noncoding RNA ZEB1\u2010AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1","volume":"8","author":"Liu CB","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12388"},{"key":"e_1_2_5_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12389"},{"key":"e_1_2_5_1_21_1","first-page":"5035","article-title":"LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer","volume":"8","author":"Zhang YY","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_22_1","first-page":"2262","article-title":"Linc\u2010POU3F3 promotes cell proliferation in gastric cancer via increasing T\u2010reg distribution","volume":"7","author":"Xiong GY","year":"2015","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_23_1","first-page":"3409","article-title":"LncRNAs BCYRN1 promoted the proliferation and migration of rat airway smooth muscle cells in asthma via upregulating the expression of transient receptor potential 1","volume":"8","author":"Zhang XY","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_24_1","first-page":"3077","article-title":"Long noncoding RNA ANRIL could be transactivated by c\u2010Myc and promote tumor progression of non\u2010small\u2010cell lung cancer","volume":"9","author":"Lu Y","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_5_1_25_1","first-page":"5444","article-title":"Long non\u2010coding RNA CCAT1 that can be activated by c\u2010Myc promotes pancreatic cancer cell proliferation and migration","volume":"8","author":"Yu QY","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_26_1","first-page":"5286","article-title":"LncRNA\u2010LINC00152 down\u2010regulated by miR\u2010376c\u20103p restricts viability and promotes apoptosis of colorectal cancer cells","volume":"8","author":"Zhang YH","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11087"},{"key":"e_1_2_5_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.05.014"},{"key":"e_1_2_5_1_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0492"},{"key":"e_1_2_5_1_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19727"},{"key":"e_1_2_5_1_31_1","first-page":"10803","article-title":"Long non\u2010coding RNA ANRIL promotes tumorigenesis in glioma via MAPK signaling pathways","volume":"9","author":"Xu XC","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_1_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1902"},{"key":"e_1_2_5_1_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0757-5"},{"key":"e_1_2_5_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1442-z"},{"key":"e_1_2_5_1_35_1","first-page":"46","article-title":"Long noncoding RNA GIHCG is a potential diagnostic and prognostic biomarker and therapeutic target for renal cell carcinoma","volume":"22","author":"He ZH","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_5_1_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12677"},{"key":"e_1_2_5_1_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.17510"},{"key":"e_1_2_5_1_38_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11528"},{"key":"e_1_2_5_1_39_1","first-page":"1271","article-title":"miR\u2010630 targets LMO3 to regulate cell growth and metastasis in lung cancer","volume":"7","author":"Song YF","year":"2015","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_40_1","first-page":"1382","article-title":"MiRNA\u201029c regulates cell growth and invasion by targeting CDK6 in bladder cancer","volume":"7","author":"Zhao X","year":"2015","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_41_1","first-page":"841","article-title":"MiR\u2010223 suppresses endometrial carcinoma cells proliferation by targeting IGF\u20101R","volume":"6","author":"Huang K","year":"2014","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12223"},{"key":"e_1_2_5_1_43_1","first-page":"1992","article-title":"MicroRNA\u2010495 suppresses human renal cell carcinoma malignancy by targeting SATB1","volume":"7","author":"Lv C","year":"2015","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12235"},{"key":"e_1_2_5_1_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12308"},{"key":"e_1_2_5_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12406"},{"key":"e_1_2_5_1_47_1","first-page":"1780","article-title":"miR\u2010141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19\u2010derived miR\u2010675","volume":"8","author":"He PH","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26691"},{"key":"e_1_2_5_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2582-z"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.27164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.27164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:57:20Z","timestamp":1744819040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.27164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/jcb.27164"],"URL":"https:\/\/doi.org\/10.1002\/jcb.27164","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"2018-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}