{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:51:37Z","timestamp":1790268697728,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Changsha Science and Technology Plan Projects","award":["[2017] 53 kq1701055"],"award-info":[{"award-number":["[2017] 53 kq1701055"]}]},{"name":"Research Foundation of Education Bureau of Hunan Province, China","award":["17B163"],"award-info":[{"award-number":["17B163"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt lymphoma is one of the most common lymphatic system cancers with poor outcome in adult patients. p53\u2010induced apoptosis is a critical signaling for preventing tumor development. Cyclin B\/cyclin\u2010dependent kinase 1 (CDK1) phosphorylates inhibitor of apoptosis stimulating protein of P53 (iASPP) to promote iASPP nucleus localization and its inhibitory effect on p53. However, p53 is frequently mutated in Burkitt lymphoma, which gains novel oncogenic properties. Recently, the p53 family member, p63, became an attractive gene for the therapeutic strategies for patients with cancer. Therefore, we investigated the role of iASPP in the transactivation domain p63 (TAp63)\u2010dependent cell proliferation inhibition in Burkitt lymphoma. We verified that the oncogenic effect of iASPP on Burkitt lymphoma is TAp63 dependent rather than p53 and confirmed that the interaction between CDK1 and iASPP enhanced the inhibitory effect of iASPP on p53 and TAp63. An online tool predicated that miR\u2010129 might bind to 3\u2032\u2010untranslated region of iASPP and CDK1. We revealed that miR\u2010129 acted as a tumor suppressor by inhibiting cancer cell proliferation and inhibiting CDK1 and iASPP via direct binding. An miR\u2010129 inhibitor increased nucleus iASPP and decreased nucleus p53 and TAp63 levels, which could be reversed by the CDK1 knockdown, indicating that miR\u2010129 might target CDK1 to inhibit iASPP phosphorylation, thus hindering iASPP nucleus localization and its inhibitory effect on p53 and TAp63 protein levels. Taken together, miR\u2010129 could targetedly inhibit the expression of CDK1 and iASPP. CDK1 knockdown inhibits iASPP S84\/S113 phosphorylation, thus blocking iASPP nucleus localization, suppressing the inhibitory effect of iASPP on p53 and TAp63, and restoring TAp63\u2010induced proliferation inhibition in Burkitt lymphoma cells.<\/jats:p>","DOI":"10.1002\/jcb.27189","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T05:43:38Z","timestamp":1534225418000},"page":"9217-9228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["miR\u2010129 targets CDK1 and iASPP to modulate Burkitt lymphoma cell proliferation in a TAp63\u2010dependent manner"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-8459","authenticated-orcid":false,"given":"Hui","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology of Children\u2019s Medical Center The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People\u2019s Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology of Children\u2019s Medical Center The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People\u2019s Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology of Children\u2019s Medical Center The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People\u2019s Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengguang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology of Children\u2019s Medical Center The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial 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