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Since multiple microRNAs could play essential roles in HSC activation and in the process of hepatic fibrosis through targeting Smads, we attempted to seek the potential microRNAs that could be involved in rSjP40\u2010induced inhibition of HSC activation. Using the method of quantitative real\u2010time PCR, we found that rSjP40 could induce miR\u2010146a expression in LX\u20102 cells. The down\u2010regulated expression levels of Smad4 and \u03b1\u2010SMA in LX\u20102 cells induced by rSjP40 were partially restored by an miR\u2010146a inhibitor. miR\u2010146a can be involved in rSjP40\u2010induced inhibition of HSC activation through targeting Smad4. These findings provide us a new idea to explore the potential mechanisms by which rSjP40 could regulate the process of hepatic fibrosis.<\/jats:p>","DOI":"10.1002\/jcb.27193","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T20:12:30Z","timestamp":1530216750000},"page":"9249-9253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["microRNA\u2010146a is involved in rSjP40\u2010inhibited activation of LX\u20102 cells by targeting Smad4 expression"],"prefix":"10.1002","volume":"119","author":[{"given":"Dandan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology School of Medicine, Nantong University  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology School of Medicine, Nantong University  Nantong Jiangsu 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