{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:48:47Z","timestamp":1766087327830,"version":"3.40.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673258","81573222"],"award-info":[{"award-number":["81673258","81573222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our study was to evaluate two lncRNAs (lnc0640 and lnc5150) expressions and gene single\u2010nucleotide polymorphisms (SNPs) in rheumatoid arthritis (RA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expressions of lncRNAs in peripheral blood mononuclear cells (PBMCs) were examined by quantitative real\u2010time reverse transcription polymerase chain reaction from 65 RA patients and 54 controls. Simultaneously, three SNPs (rs13039216, rs6085189, and rs6085190) of <jats:italic>lnc0640,<\/jats:italic> three SNPs (rs1590666, rs141561256, and rs144047453) of <jats:italic>lnc5150<\/jats:italic> were genotyped using TaqMan SNP\u2010genotyping assays in 627 RA patients and 590 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lnc0640 level in PBMCs from RA patients was significantly increased (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), whereas the lnc5150 level was significantly reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) compared to controls. There were significant associations of lnc0640 and lnc5150 levels with C\u2010reactive protein in RA patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.011 and <jats:italic>P<\/jats:italic>\u2009=\u20090.014, respectively), while lnc5150 level was associated with erythrocyte sedimentation rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.022). TT genotype of rs13039216 in <jats:italic>lnc0640<\/jats:italic> gene was statistically associated with a reduced risk of RA (TT vs CC; <jats:italic>P<\/jats:italic>\u2009=\u20090.046), and a decreased risk of rs13039216 variant was observed under the recessive model (<jats:italic>P<\/jats:italic>\u2009=\u20090.038). In addition, the G allele of rs141561256 polymorphism in <jats:italic>lnc5150<\/jats:italic> gene was significantly associated with rheumatoid factor in RA patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.034). There were no associations between lnc0640 and lnc5150 levels and their respective genotype in RA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The expressions of lnc0640 and lnc5150 were alternated in the RA patients, suggesting that these lncRNAs may involve in the development of RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.27346","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:09:51Z","timestamp":1534954191000},"page":"10095-10106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The expression levels of long noncoding RNAs lnc0640 and lnc5150 and its gene single\u2010nucleotide polymorphisms in rheumatoid arthritis patients"],"prefix":"10.1002","volume":"119","author":[{"given":"Tian\u2010Ping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui 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