{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:12:45Z","timestamp":1744863165318,"version":"3.40.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772209"],"award-info":[{"award-number":["81772209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syphilis is a sexually transmitted disease caused by the infection of <jats:italic>Treponema pallidum<\/jats:italic> subspecies pallidum. T\u2010helper type 17\u2013related genes, vitamin D receptor (VDR) gene, and chemokine\/chemokine receptor genes are crucial in microbial infection. A total of 16 single\u2010nucleotide polymorphisms (SNPs) in eight genes (interleukin [IL]\u201017A, IL\u201017F, IL\u201023R, VDR, C\u2010C motif chemokine ligand [CCL] 2, CCL5, C\u2010C chemokine receptor [CCR] 2, and CCR5) were analyzed in 188 patients with syphilis and 216 healthy controls. The results showed a strong correlation of IL\u201017A rs2275913 (AA vs AG\u2009+\u2009GG: odds ratio [OR], 1.78; 95% confidence interval [CI], 1.09 to 2.92; <jats:italic>P<\/jats:italic>\u2009=\u20090.020; A vs G: OR, 1.33; 95% CI, 1.01 to 1.76; <jats:italic>P<\/jats:italic>\u2009=\u20090.043) and rs3819024 (GG vs AA\u2009+\u2009GA: OR, 1.76; 95% CI, 1.06 to 2.91; <jats:italic>P<\/jats:italic>\u2009=\u20090.028; G vs A: OR, 1.36; 95% CI, 1.03 to 1.80; <jats:italic>P<\/jats:italic>\u2009=\u20090.030) with syphilis. In haplotype analysis, IL\u201017A rs2275913A\/rs3819024G showed a risk effect (OR, 1.38; 95% CI, 1.04 to 1.82; <jats:italic>P<\/jats:italic>\u2009=\u20090.026), whereas IL\u201017A rs2275913G\/rs3819024A showed a protective effect (OR, 0.76; 95% CI, 0.57 to 0.998; <jats:italic>P<\/jats:italic>\u2009=\u20090.048). The expression levels of\u00a0IL\u201017A messenger RNA (mRNA) in peripheral blood mononuclear cells and IL\u201017A secretion in plasma were further examined. No significant differences were found between patients with syphilis and healthy controls. The study also explored whether IL\u201017A rs2275913 and rs3819024 were associated with the expression of IL\u201017A mRNA and IL\u201017A secretion in patients with syphilis. Similar negative results were found. In conclusion, the polymorphisms of IL\u201017A rs2275913 and rs3819024 and the haplotype containing these two SNPs influenced the susceptibility to syphilis in a Han Chinese population.<\/jats:p>","DOI":"10.1002\/jcb.27352","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T10:29:05Z","timestamp":1535797745000},"page":"10151-10164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of IL\u201017A, IL\u201017F, IL\u201023R, VDR, CCL2, CCL5, CCR2, and CCR5 gene polymorphisms and expression in Chinese individuals with syphilis"],"prefix":"10.1002","volume":"119","author":[{"given":"Wen\u2010Long","family":"Hu","sequence":"first","affiliation":[{"name":"Department of STD Control Institute of Dermatology, Chinese Academy of Medical Science &amp; Peking Union Medical College,\u00a0National Center for STD Control, Chi Centers for Disease Control and Prevention Nanjing 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