{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:14:56Z","timestamp":1790248496535,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402193"],"award-info":[{"award-number":["81402193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500029"],"award-info":[{"award-number":["81500029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["BS2015YY005"],"award-info":[{"award-number":["BS2015YY005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>KDM6B, also known as JMJD3, is a member of the family of histone lysine demethylase (KDMs), which is closely related to many types of cancers. However, its role and the underlying mechanisms in ovarian cancer remain unknown. Here we show that KDM6B is elevated in epithelial ovarian cancer and its expression level is closely related with metastasis and invasion. In addition, survival analysis showed that high expression of KDM6B was associated with low overall survival in ovarian cancer patients. Overexpression of KDM6B in epithelial ovarian cancer cells promoted proliferation, epithelial\u2010mesenchymal transition (EMT), migration and invasion in vitro, and enhanced metastatic capacities in vivo. On the contrary, silencing KDM6B in invasive and metastatic ovarian cancer cells inhibited these processes. Mechanistically, we found that KDM6B exerts its function by modulating the transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) expression, and TGF\u2010\u03b21 signal pathway inhibitor LY2157299 significantly inhibited KDM6B\u2010induced proliferation, migration, metastasis, and EMT in ovarian cancer cells. Our findings, for the first time, reveal the pivotal role of KDM6B in the invasion and metastatic behavior of epithelial ovarian cancer. Thus, targeting KDM6B may be a useful strategy to interfere with these behaviors of epithelial ovarian cancer.<\/jats:p>","DOI":"10.1002\/jcb.27405","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T06:51:05Z","timestamp":1536735065000},"page":"493-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Retracted<\/i>: KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor\u2010\u03b21 expression"],"prefix":"10.1002","volume":"120","author":[{"given":"Shumei","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Qilu Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4873-054X","authenticated-orcid":false,"given":"Yun\u2010shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60031-3"},{"key":"e_1_2_7_1_4_1","first-page":"449","article-title":"The value of secondary cytoreductive surgery in recurrent ovarian cancer and application of a prognostic score","volume":"26","author":"da Costa AA","year":"2016","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.10.009"},{"key":"e_1_2_7_1_6_1","article-title":"Secondary surgery versus chemotherapy for recurrent ovarian cancer","author":"Bickell NA","year":"2016","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.007"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0307-9"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2182"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200601018"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.034"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-016-9648-7"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125150"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1835"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.019"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06192"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2007.83"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.510809"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr399"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.579"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.349"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.424903"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22188"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-252"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06145"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9152"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.01.006"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0536"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2016.03.002"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4879-3"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu136"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.029"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0509-3"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0502-x"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0487-x"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.02.001"}],"updated-by":[{"DOI":"10.1002\/jcb.30253","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000}}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.27405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.27405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:25:08Z","timestamp":1732811108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.27405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/jcb.27405"],"URL":"https:\/\/doi.org\/10.1002\/jcb.27405","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1002\/jcb.30253","asserted-by":"object"}]},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,11]]},"assertion":[{"value":"2017-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}