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The following study investigates the interaction of EGFR and IL\u20106R in lung cancer. In the current study, EGFR, IL\u20106, and glycoprotein 130 (GP130) were highly expressed in non\u2013small cell lung cancer (NSCLC) tissue samples and were associated with clinicopathological features and poor prognosis of patients with NSCLC. Furthermore, the effect of EGF and IL\u20106 on biological behavior of lung cancer cells (cell proliferation, invasion, cycle, and apoptosis) and the expression of EGFR, GP130, p\u2010protein kinase B (p\u2010AKT), and p\u2010p44\/42 mitogen\u2010activated protein kinase (p\u2010p44\/42 MAPK) was significantly stronger compared with other treatment groups (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). These results suggest that EGFR and IL\u20106R have synergistic effects on NSCLC progression. This could help to solve the problem of EGFR inhibitors in the treatment of lung cancer resistance and improve the efficacy of current treatment for lung cancer through a combination of EGFR and IL\u20106R signaling pathways.<\/jats:p>","DOI":"10.1002\/jcb.27448","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:08:19Z","timestamp":1534954099000},"page":"872-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interaction between epidermal growth factor receptor and interleukin\u20106 receptor in NSCLC progression"],"prefix":"10.1002","volume":"120","author":[{"given":"Bai","family":"Yuquan","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Zhongnan Hospital of Wuhan University Donghu Road Wuhan 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