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However, its potential role in osteocytes has not been explored. In this study, we deleted <jats:italic>Raptor<\/jats:italic>, a specific and essential component of mTORC1, in osteocytes using <jats:italic>Dmp1\u2010Cre<\/jats:italic>. Deletion of <jats:italic>Raptor<\/jats:italic> in osteocytes did not affect bone development and growth, but caused compartment\u2010specific effects on bone mass. Osteocyte\u2010specific deletion of <jats:italic>Raptor<\/jats:italic> had no obvious effect on cortical bone compartments, but led to increased trabecular bone mass. Mechanistically, <jats:italic>Raptor<\/jats:italic> deletion resulted in decreased bone resorption without altering bone formation activity. Thus, our study revealed an unexpected role of osteocyte\u2010intrinsic mTORC1 signaling in limiting trabecular bone mass, suggesting that osteocyte\u2010specific inhibition of mTORC1 may be used as a novel approach to treatment of osteoporosis.<\/jats:p>","DOI":"10.1002\/jcb.27470","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T19:08:33Z","timestamp":1535656113000},"page":"8743-8749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Osteocyte\u2010intrinsic mTORC1 signaling restrains trabecular bone accrual in mice"],"prefix":"10.1002","volume":"119","author":[{"given":"Qingbai","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Department of Orthopedics Lianshui County People's Hospital Huaian 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