{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:27:11Z","timestamp":1769610431091,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation of Hebei Province Plan","award":["H2015209043"],"award-info":[{"award-number":["H2015209043"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously showed that changes in calcium concentrations were related to cell apoptosis in vitro. The endoplasmic reticulum (ER) is the main component of calcium storage and signal transduction, and disrupting the balance of intracellular Ca<jats:sup>2+<\/jats:sup> can cause endoplasmic reticulum stress (ERS). In this process, the ER releases stored Ca\n<jats:sup>2+<\/jats:sup> into the cytoplasm and activates calpain\u20102. To further investigate the effect of calpain in hepatic stellate cells (HSCs), in the current study, we examine the effect of \n<jats:italic>N<\/jats:italic>\u2010acetyl\u2010leu\u2010leu\u2010norleucinal (ALLN) on apoptosis resulting from calcium ionophore A23187\u2013induced ERS. Our findings indicate that calpain inhibition reduces calcium ionophore A23187\u2013induced apoptosis of HSCs and decreases the expression of ER stress proteins that may be related to the calpain\/caspase signaling pathway.<\/jats:p>","DOI":"10.1002\/jcb.27478","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T02:44:07Z","timestamp":1536288247000},"page":"1685-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of calpain inhibitor on the apoptosis of hepatic stellate cells induced by calcium ionophore A23187"],"prefix":"10.1002","volume":"120","author":[{"given":"Yanan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Health Statistics School of Public Health, North China University of Science and Technology Hebei 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