{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:40:53Z","timestamp":1791812453530,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860447"],"award-info":[{"award-number":["81860447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The soluble form of guanylyl cyclase (sGC) is the main receptor for the signaling agent nitric oxide (NO), which regulates cardiomyocyte contractile function and attenuates cardiomyocyte hypertrophy. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), a regulator of vascular tone, and cardiac NO\u2010sGC\u2010cGMP signaling modulates cardiac stress responses, including ischemia and reperfusion (IR) injury. Here, we investigated the role of GUCY1B3 (the \u03b2 subunit of sGC) in cardiomyocyte IR injury and myocardial infarction (MI) in vitro and in vivo. GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to IR injury, and GUCY1B3 overexpression restored IR\u2010induced cell death and apoptosis. Treatment with specific inhibitors of PKC\u03b4, PKC\u03b5, and Akt suggested that the protective effects of GUCY1B3 were mediated by PKC\u03b5\/Akt signaling. In a mouse model of coronary artery ligation\u2010induced MI, GUCY1B3 silencing aggravated MI\u2010induced cardiac dysfunction and increased infarct size and exacerbated cardiomyocyte apoptosis in association with the inactivation of PKC\u03b5 and Akt. Our results suggest that GUCY1B3 exerts cardioprotective effects through the modulation of the PKC\u03b5\/Akt activity and identify a potential mechanism involved in NO\u2010sGC\u2010cGMP signaling in the heart.<\/jats:p>","DOI":"10.1002\/jcb.27479","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T14:06:24Z","timestamp":1543413984000},"page":"3071-3081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The \u03b2 subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKC\u03b5\/Akt pathway"],"prefix":"10.1002","volume":"120","author":[{"given":"Xiaomin","family":"Wang","sequence":"first","affiliation":[{"name":"Translational Medicine Center, Baotou Central Hospital Baotou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of 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