{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:55:18Z","timestamp":1791888918044,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.SBMU.RIDS.REC.1394.8"],"award-info":[{"award-number":["IR.SBMU.RIDS.REC.1394.8"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontal disease is a common chronic inflammatory disease of the oral cavity. This disease occurs as a consequence of uncontrolled inflammatory immune responses against periodontopathic bacteria. Several studies have documented the proinflammatory roles of the Signal Transducer and Activator of Transcription 1 (STAT1) and Wnt5a in inflammatory diseases. However, there has been no detailed investigation of <jats:italic>STAT1<\/jats:italic> and <jats:italic>Wnt5a<\/jats:italic> genes expression in periodontal disease. So, we aimed to evaluate the expressions of <jats:italic>STAT1<\/jats:italic> and <jats:italic>Wnt5a<\/jats:italic> in patients with chronic and aggressive periodontitis and determine their correlation with clinical parameters. Three groups of subjects were enrolled including control (20 healthy individuals), chronic (25 patients), and aggressive periodontitis patients (25 patients). The expressions of <jats:italic>STAT1<\/jats:italic> and <jats:italic>Wnt5a<\/jats:italic> were evaluated in gingival tissue samples using a Real\u2010time polymerase chain reactions assay. The expressions of <jats:italic>STAT1<\/jats:italic> and <jats:italic>Wnt5a<\/jats:italic> were significantly upregulated in chronic and aggressive periodontitis compared with the healthy control. We also found that the expressions of STAT1 and Wnt5a increased in aggressive periodontitis compared with chronic periodontitis. In addition, there was the linear relationship between the expression of STAT1 and Wnt5a and the clinical parameters, including clinical attachment loss and periodontal pocket depth. A linear relationship between the expressions of Wnt5a and the clinical parameters was also identified. Taken together, our findings highlight the roles of STAT1 and Wnt5a in the pathogenesis of the periodontal inflammation, suggesting these molecules as valuable therapeutic targets.<\/jats:p>","DOI":"10.1002\/jcb.27487","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T20:50:14Z","timestamp":1539636614000},"page":"1827-1834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of <i>STAT1<\/i> and <i>Wnt5a<\/i> gene expression in gingival tissues of patients with periodontal disease"],"prefix":"10.1002","volume":"120","author":[{"given":"Saeed Mohammadian","family":"Haftcheshmeh","sequence":"first","affiliation":[{"name":"Department of Medical immunology, Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Medical Immunology Faculty of Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadollah","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Cellular &amp; Molecular Research Center, Faculty of Medicine, Kurdistan University of Medical Sciences Sanandaj Iran"},{"name":"Department of Medical Biochemistry, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Soltani","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-1083","authenticated-orcid":false,"given":"Amir Abbas","family":"Momtazi\u2010Borojeni","sequence":"additional","affiliation":[{"name":"Nanotechnology Research Center, Bu\u2010Ali Research Institute Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Sattari","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology Faculty of Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01408.x"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.53"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00821.x"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00189.x"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2013.8"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.013276"},{"key":"e_1_2_8_1_11_1","first-page":"273","article-title":"STAT3\u2010induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer","volume":"19","author":"Katoh M","year":"2007","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.12.006"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150319"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81288-X"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054546645"},{"key":"e_1_2_8_1_16_1","first-page":"ZE21","article-title":"C\u2010reactive protein (CRP) and its association with periodontal disease: a brief review","volume":"8","author":"Bansal T","year":"2014","journal-title":"J Clin Diagn Res: JCDR"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.2478\/folmed-2014-0022"},{"key":"e_1_2_8_1_18_1","first-page":"462","article-title":"Periodontal disease: mechanisms of infection and inflammation and possible impact on miscellaneous systemic diseases and conditions: clinical","volume":"68","author":"Mohangi GU","year":"2013","journal-title":"S Afr Dent J"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.4886"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v25.i2.10"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00113.x"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070501"},{"key":"e_1_2_8_1_25_1","first-page":"4","article-title":"Rheumatoid arthritis and periodontitis\u2010inflammatory and infectious connections. 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