{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:31:49Z","timestamp":1775788309757,"version":"3.50.1"},"reference-count":202,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["HL-74815"],"award-info":[{"award-number":["HL-74815"]}]},{"name":"National Institute of Health","award":["AR071789"],"award-info":[{"award-number":["AR071789"]}]},{"name":"National Institute of Health","award":["and HL-139047"],"award-info":[{"award-number":["and HL-139047"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Higher levels of nonprotein amino acid homocysteine (Hcy), that is, hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with severe vasculopathies in different organs; however, precise molecular mechanism(s) as to how HHcy plays havoc with body\u2019s vascular networks are largely unknown. Interventional modalities have not proven beneficial to counter multifactorial HHcy\u2019s effects on the vascular system. An ancient Indian form of exercise called \u2018yoga\u2019 causes transient ischemia as a result of various body postures however the cellular mechanisms are not clear. We discuss a novel perspective wherein we argue that application of remote ischemic conditioning (RIC) could, in fact, deliver anticipated results to patients who are suffering from chronic vascular dysfunction due to HHcy. RIC is the mechanistic phenomenon whereby brief episodes of ischemia\u2010reperfusion events are applied to distant tissues\/organs; that could potentially offer a powerful tool in mitigating chronic lethal ischemia in target organs during HHcy condition via simultaneous reduction of inflammation, oxidative and endoplasmic reticulum stress, extracellular matrix remodeling, fibrosis, and angiogenesis. We opine that during ischemic conditioning our organs cross talk by releasing cellular messengers in the form of exosomes containing messenger RNAs, circular RNAs, anti\u2010pyroptotic factors, protective cytokines like musclin, transcription factors, small molecules, anti\u2010inflammatory, antiapoptotic factors, antioxidants, and vasoactive gases. All these could help mobilize the bone marrow\u2013derived stem cells (having tissue healing properties) to target organs. In that context, we argue that RIC could certainly play a savior\u2019s role in an unfortunate ischemic or adverse event in people who have higher levels of the circulating Hcy in their systems.<\/jats:p>","DOI":"10.1002\/jcb.27603","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T07:37:44Z","timestamp":1536651464000},"page":"77-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-2242","authenticated-orcid":false,"given":"Avisek","family":"Majumder","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"},{"name":"Department of Biochemistry and Molecular Genetics School of Medicine, University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahavir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"},{"name":"Eye and Vision Science Laboratory University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash K.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"},{"name":"Eye and Vision Science Laboratory University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Petit","family":"Homme","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"},{"name":"Eye and Vision Science Laboratory University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwesha","family":"Laha","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-9006-9"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11058-9"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140715074"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0706-5"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.79.56.319"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-010-9079-y"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.3.553"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402112666161010151632"},{"key":"e_1_2_10_1_10_1","first-page":"308","article-title":"Folic acid and vitamin B6 deficiencies related hyperhomocysteinemia in apparently healthy Pakistani adults; is mass micronutrient supplementation indicated in this population?","volume":"19","author":"Iqbal MP","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009007500021"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2004.01.001"},{"key":"e_1_2_10_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.12.014"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25841"},{"key":"e_1_2_10_1_15_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0037"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.01.008"},{"key":"e_1_2_10_1_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011252"},{"key":"e_1_2_10_1_18_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0059"},{"key":"e_1_2_10_1_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.147439"},{"key":"e_1_2_10_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2193"},{"key":"e_1_2_10_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.3.893"},{"key":"e_1_2_10_1_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.1124"},{"key":"e_1_2_10_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn114"},{"key":"e_1_2_10_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.031"},{"key":"e_1_2_10_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61296-3"},{"key":"e_1_2_10_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.155770"},{"key":"e_1_2_10_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0104-5"},{"key":"e_1_2_10_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.156"},{"key":"e_1_2_10_1_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0b013e3181c572bd"},{"key":"e_1_2_10_1_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.5.1641"},{"key":"e_1_2_10_1_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000043806.51912.9B"},{"key":"e_1_2_10_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12448"},{"key":"e_1_2_10_1_33_1","doi-asserted-by":"publisher","DOI":"10.5758\/vsi.2016.32.4.141"},{"key":"e_1_2_10_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12833-2"},{"key":"e_1_2_10_1_35_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21238"},{"key":"e_1_2_10_1_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.117.001720"},{"key":"e_1_2_10_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.05.026"},{"key":"e_1_2_10_1_38_1","doi-asserted-by":"publisher","DOI":"10.5493\/wjem.v5.i4.218"},{"key":"e_1_2_10_1_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317700"},{"key":"e_1_2_10_1_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.055848"},{"key":"e_1_2_10_1_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200501800308"},{"key":"e_1_2_10_1_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-S1-S4"},{"key":"e_1_2_10_1_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118776"},{"key":"e_1_2_10_1_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.4.F671"},{"key":"e_1_2_10_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.12.028"},{"key":"e_1_2_10_1_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2010"},{"key":"e_1_2_10_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.01.001"},{"key":"e_1_2_10_1_48_1","first-page":"881","article-title":"A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age\u2010related macular degeneration","volume":"11","author":"George AK","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_10_1_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_10_1_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1809"},{"key":"e_1_2_10_1_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11596"},{"key":"e_1_2_10_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385114-7.00004-0"},{"key":"e_1_2_10_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.06.007"},{"key":"e_1_2_10_1_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402200"},{"key":"e_1_2_10_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.12.009"},{"key":"e_1_2_10_1_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652406775574596"},{"key":"e_1_2_10_1_57_1","first-page":"275","article-title":"Dietary intake of vitamins B6, B12 and folate in relation to homocysteine serum concentration in the adult Polish population \u2010 WOBASZ Project","volume":"68","author":"Wa\u015bkiewicz A","year":"2010","journal-title":"Kardiol Pol"},{"key":"e_1_2_10_1_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199802270-00016"},{"key":"e_1_2_10_1_59_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830515Y.0000000041"},{"key":"e_1_2_10_1_60_1","first-page":"696","article-title":"Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells","volume":"10","author":"Singh M","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_10_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2017.06.012"},{"key":"e_1_2_10_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.01.003"},{"key":"e_1_2_10_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.07.006"},{"key":"e_1_2_10_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.222"},{"key":"e_1_2_10_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.016"},{"key":"e_1_2_10_1_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2449"},{"key":"e_1_2_10_1_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07203"},{"key":"e_1_2_10_1_68_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2009.31.2.1357292"},{"key":"e_1_2_10_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2009.04.030"},{"key":"e_1_2_10_1_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659114536760"},{"key":"e_1_2_10_1_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8538-z"},{"key":"e_1_2_10_1_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104324200"},{"key":"e_1_2_10_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3904"},{"key":"e_1_2_10_1_74_1","first-page":"266","article-title":"Remodeling in vein expresses arterial phenotype in hyperhomocysteinemia","volume":"3","author":"Basu P","year":"2011","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"e_1_2_10_1_75_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0060"},{"key":"e_1_2_10_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"e_1_2_10_1_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0260-x"},{"key":"e_1_2_10_1_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.223"},{"key":"e_1_2_10_1_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0588-8"},{"key":"e_1_2_10_1_80_1","first-page":"51","article-title":"Hypoxia\u2010inducible factor (HIF)\u20101 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia","volume":"80","author":"Ziello JE","year":"2007","journal-title":"Yale J Biol Med"},{"key":"e_1_2_10_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"e_1_2_10_1_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066373"},{"key":"e_1_2_10_1_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192342099"},{"key":"e_1_2_10_1_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317158110"},{"key":"e_1_2_10_1_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.758516"},{"key":"e_1_2_10_1_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.084855"},{"key":"e_1_2_10_1_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.186809"},{"key":"e_1_2_10_1_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu172"},{"key":"e_1_2_10_1_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.10.001"},{"key":"e_1_2_10_1_90_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1171"},{"key":"e_1_2_10_1_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31815d88c9"},{"key":"e_1_2_10_1_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0377-6"},{"key":"e_1_2_10_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.037"},{"key":"e_1_2_10_1_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003891"},{"key":"e_1_2_10_1_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707409"},{"key":"e_1_2_10_1_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.024"},{"key":"e_1_2_10_1_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.03.019"},{"key":"e_1_2_10_1_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00046.2004"},{"key":"e_1_2_10_1_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-46"},{"key":"e_1_2_10_1_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31821d8e77"},{"key":"e_1_2_10_1_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00374.2004"},{"key":"e_1_2_10_1_102_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/620681"},{"key":"e_1_2_10_1_103_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013070708"},{"key":"e_1_2_10_1_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00339"},{"key":"e_1_2_10_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.023"},{"key":"e_1_2_10_1_106_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00003.2014"},{"key":"e_1_2_10_1_107_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1920"},{"key":"e_1_2_10_1_108_1","first-page":"1659","article-title":"Camk2b protects neurons from homocysteine\u2010induced apoptosis with the involvement of HIF\u20101alpha signal pathway","volume":"7","author":"Fang M","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_10_1_109_1","first-page":"93","article-title":"The role of skeletal muscle in the regulation of glucose homeostasis","volume":"9","author":"Otto Buczkowska E","year":"2003","journal-title":"Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw"},{"key":"e_1_2_10_1_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"e_1_2_10_1_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.004"},{"key":"e_1_2_10_1_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0423-z"},{"key":"e_1_2_10_1_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.015"},{"key":"e_1_2_10_1_114_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.17.0563"},{"key":"e_1_2_10_1_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"e_1_2_10_1_116_1","first-page":"233","article-title":"Evaluation of homocysteine level as a risk factor among patients with ischemic stroke and its subtypes","volume":"38","author":"Ashjazadeh N","year":"2013","journal-title":"Iran J Med Sci"},{"key":"e_1_2_10_1_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.11.015"},{"key":"e_1_2_10_1_118_1","unstructured":"Stroke 2015 Elevated total homocysteine levels in acute ischemic stroke are associated with long\u2010term mortality"},{"key":"e_1_2_10_1_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(88)90547-5"},{"key":"e_1_2_10_1_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0202-9"},{"key":"e_1_2_10_1_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.11.005"},{"key":"e_1_2_10_1_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0314-0"},{"key":"e_1_2_10_1_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36758"},{"key":"e_1_2_10_1_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2005"},{"key":"e_1_2_10_1_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.058"},{"key":"e_1_2_10_1_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.03.005"},{"key":"e_1_2_10_1_127_1","unstructured":"Biochimica et biophysica acta 2006"},{"key":"e_1_2_10_1_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00040"},{"key":"e_1_2_10_1_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70054-7"},{"key":"e_1_2_10_1_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101733"},{"key":"e_1_2_10_1_131_1","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully KS","year":"1969","journal-title":"Am J Pathol"},{"key":"e_1_2_10_1_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.020"},{"key":"e_1_2_10_1_133_1","first-page":"544","article-title":"Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress","volume":"35","author":"Hrncic D","year":"2014","journal-title":"Int J Sports Med"},{"key":"e_1_2_10_1_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.01.001"},{"key":"e_1_2_10_1_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703576114"},{"key":"e_1_2_10_1_136_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2282"},{"key":"e_1_2_10_1_137_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/357824"},{"key":"e_1_2_10_1_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.197"},{"key":"e_1_2_10_1_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23568-z"},{"key":"e_1_2_10_1_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908047106"},{"key":"e_1_2_10_1_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.026"},{"key":"e_1_2_10_1_142_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.268re2"},{"key":"e_1_2_10_1_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000721"},{"key":"e_1_2_10_1_144_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033391405"},{"key":"e_1_2_10_1_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/21224"},{"key":"e_1_2_10_1_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.03.019"},{"key":"e_1_2_10_1_147_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9719"},{"key":"e_1_2_10_1_148_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000203555.14546.63"},{"key":"e_1_2_10_1_149_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100598"},{"key":"e_1_2_10_1_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22272"},{"key":"e_1_2_10_1_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181b2b72b"},{"key":"e_1_2_10_1_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_2_10_1_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8421-y"},{"key":"e_1_2_10_1_154_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791959783"},{"key":"e_1_2_10_1_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.74"},{"key":"e_1_2_10_1_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24722"},{"key":"e_1_2_10_1_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00559-2"},{"key":"e_1_2_10_1_158_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.4.H1707"},{"key":"e_1_2_10_1_159_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1542"},{"key":"e_1_2_10_1_160_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.5.H1571"},{"key":"e_1_2_10_1_161_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2072"},{"key":"e_1_2_10_1_162_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2004.26.2.800064"},{"key":"e_1_2_10_1_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.034"},{"key":"e_1_2_10_1_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005348"},{"key":"e_1_2_10_1_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.10.008"},{"key":"e_1_2_10_1_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00266-2"},{"key":"e_1_2_10_1_167_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.62.512"},{"key":"e_1_2_10_1_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-3-4"},{"key":"e_1_2_10_1_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.10.006"},{"key":"e_1_2_10_1_170_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.986497"},{"key":"e_1_2_10_1_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.11.056"},{"key":"e_1_2_10_1_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.029"},{"key":"e_1_2_10_1_173_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000115161.10646.67"},{"key":"e_1_2_10_1_174_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175732"},{"key":"e_1_2_10_1_175_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200211150-00009"},{"key":"e_1_2_10_1_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.06.037"},{"key":"e_1_2_10_1_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr103"},{"key":"e_1_2_10_1_178_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8407"},{"key":"e_1_2_10_1_179_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444900"},{"key":"e_1_2_10_1_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00006.x"},{"key":"e_1_2_10_1_181_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.099499"},{"key":"e_1_2_10_1_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.02.010"},{"key":"e_1_2_10_1_183_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20529"},{"key":"e_1_2_10_1_184_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34616"},{"key":"e_1_2_10_1_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.00005.x"},{"key":"e_1_2_10_1_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0930-2"},{"key":"e_1_2_10_1_187_1","first-page":"298","article-title":"Homocysteine plasma concentration is related to severity of lung impairment in scleroderma","volume":"30","author":"Caramaschi P","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_10_1_188_1","doi-asserted-by":"publisher","DOI":"10.31768\/2312-8852.2015.37(3):218-222"},{"key":"e_1_2_10_1_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.072"},{"key":"e_1_2_10_1_190_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01055.2001"},{"key":"e_1_2_10_1_191_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i10.1308"},{"key":"e_1_2_10_1_192_1","unstructured":"Acta biochimica et biophysica Sinica"},{"key":"e_1_2_10_1_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou022"},{"key":"e_1_2_10_1_194_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmu076"},{"key":"e_1_2_10_1_195_1","first-page":"w14293","article-title":"Gastro\u2010intestinal tract: The leading role of mucosal immunity","volume":"146","author":"Steinert A","year":"2016","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_10_1_196_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37192"},{"key":"e_1_2_10_1_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10041"},{"key":"e_1_2_10_1_198_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318191bcd6"},{"key":"e_1_2_10_1_199_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00106.2003"},{"key":"e_1_2_10_1_200_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197606000-00008"},{"key":"e_1_2_10_1_201_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13858"},{"key":"e_1_2_10_1_202_1","first-page":"195","article-title":"Homocystinuria with bilateral absolute glaucoma","volume":"33","author":"Kalra BR","year":"1985","journal-title":"Indian J Ophthalmol"},{"key":"e_1_2_10_1_203_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00147.2018"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.27603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.27603","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:25:19Z","timestamp":1732811119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.27603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,11]]},"references-count":202,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/jcb.27603"],"URL":"https:\/\/doi.org\/10.1002\/jcb.27603","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,11]]},"assertion":[{"value":"2018-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}