{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:10:14Z","timestamp":1773475814945,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/HRD\/35\/02\/2006"],"award-info":[{"award-number":["BT\/HRD\/35\/02\/2006"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["YSS\/2015\/001279"],"award-info":[{"award-number":["YSS\/2015\/001279"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toll\/interleukin\u20101 like receptors (TLRs) are membrane\u2010spanning proteins crucially involved in innate immunity. On activation, the cytoplasmic toll\/interleukin\u20101 receptor (TIR) domains of these receptors undergo homo\u2010 or heterodimerization. \n<jats:italic>Brucella sp<\/jats:italic>. are bacterial pathogens that affect the immune system by suppressing the TLR signaling pathway. They enact this by encoding a TIR domain\u2013containing protein, TcpB, which suppresses NF\u2010\u03baB activation and proinflammatory cytokine secretion mediated by TLR4 receptors. TcpB has been shown to target the Mal\u2010mediated pathway to suppress TLR signaling. The recent identification of its mechanism of interference with TLR4 signaling involving Mal prompted us to further study the structural aspects of TcpB binding with TLR4 and Mal. Our triprotein model displays the overall scaffolding role of TcpB in anchoring TLR4 and Mal thereby inhibiting their interaction leading to the attenuation of the TLR4 pathway.<\/jats:p>","DOI":"10.1002\/jcb.27619","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T13:10:36Z","timestamp":1537621836000},"page":"3455-3458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Scaffolding role of TcpB in disrupting TLR4\u2010Mal interactions: Three to tango"],"prefix":"10.1002","volume":"120","author":[{"given":"Uzma","family":"Saqib","sequence":"first","affiliation":[{"name":"Discipline of Chemistry, School of Basic Sciences, Indian Institute of Technology, Indore Indore Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-1353","authenticated-orcid":false,"given":"Mirza S","family":"Baig","sequence":"additional","affiliation":[{"name":"Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IITI)  Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040021"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110577"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1734"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.523274"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.11.104"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00028"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060613"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh354"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22835"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802651562"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902008"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.27619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.27619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.27619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:05:22Z","timestamp":1728288322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.27619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,22]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/jcb.27619"],"URL":"https:\/\/doi.org\/10.1002\/jcb.27619","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,22]]},"assertion":[{"value":"2018-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}