{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:21:00Z","timestamp":1774441260770,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["95\/04"],"award-info":[{"award-number":["95\/04"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute lymphoblastic leukemia (ALL) is characterized by excessive accumulation of lymphoblast and progenitors. Leukemia is the most common cancer in children and ALL is the most common subtype. Many studies have shown that the YKL\u201040 gene is one of the most widely expressed genes in tumors, including leukemia, but not in healthy blood cells. Clinical studies have shown that serum YKL\u201040 levels have a positive correlation with tumor expansion, in addition to being a prognostic agent independent of a short relapse\u2010free interval, as well as a brief overall survival in patients with various cancers. The previous study shows that YKL\u201040 is closely related to the degree of pathology or degree of human leukemia pathology and plays an important role in cell proliferation. Hence, the YKL\u201040 can be an attractive target in designing anticancer therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CCRF\u2010CEM cells were treated with resveratrol and prednisolone. For analysis of YKL\u201040 expression changes under medication, real\u2010time polymerase chain reaction (PCR) and Western blot techniques were used at resonating intervals of 24 and 48\u2009hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect of 15, 50, and 100\u2009\u03bcM resveratrol and 700\u2009\u03bcM of prednisolone on CCRF\u2010CEM cells reduced YKL\u201040. The YKL\u201040 gene was quantitatively measured using RT\u2010PCR. The Western blot method was used to evaluate changes in the expression of YKL\u201040 protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we first evaluated YKL\u201040 expression and resveratrol and prednisolone effect on YKL\u201040 in ALL. This finding supports the idea of targeting YKL\u201040 as a new drug treatment of ALL and extends the use of resveratrol in antileukemia research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.27659","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T06:15:18Z","timestamp":1542176118000},"page":"3773-3779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of tumor suppressor of resveratrol and prednisolone by downregulation of YKL\u201040 expression in CCRF\u2010CEM cell line"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-4272","authenticated-orcid":false,"given":"Milad","family":"Zadi Heydarabad","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz 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