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To date, the proteomic changes in skin lesions from HHD patients has not been reported yet. In this study, a sample of skin lesions from HHD patients was collected for isobaric tags for relative and absolute quantitation to analyze proteome changes compared with unaffected individuals. The 134 differentially expressed proteins were assigned to at least one Gene Ontology term, and 123 annotated proteins with significant matches were assigned to 187 known metabolic or signaling pathways listed in the Kyoto Encyclopedia of Genes and Genomes. Most of the altered proteins in skin lesions of HHD patients were enriched in pathways involved in the PI3K\u2010Akt signaling, focal adhesion, extracellular matrix (ECM)\u2010receptor interaction, and protein digestion and absorption, such as collagen family members, microfibril\u2010associated glycoprotein 4 and plakophilin. The changes of proteins related to cell adhesion, ECM\u2010receptor interaction, and protein folding and glycosylation suggested that strategy targeted to alter cell junction and extracellular microenvironment might provide a potential treatment for HHD.<\/jats:p>","DOI":"10.1002\/jcb.27662","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T03:30:23Z","timestamp":1543807823000},"page":"3801-3812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered levels of focal adhesion and extracellular matrix\u2010receptor interacting proteins were identified in Hailey\u2010Hailey disease by quantitative iTRAQ proteome analysis"],"prefix":"10.1002","volume":"120","author":[{"given":"Dingwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Hospital of Xi'an Jiaotong University Xi'an 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