{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:30:50Z","timestamp":1792956650220,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial ischemia\u2010reperfusion (I\/R) injury is thought to have its detrimental role in coronary heart disease (CHD), which is considered as the foremost cause of death all over the world. However, molecular mechanism in the progression of myocardial I\/R injury is still unclear. The goal of this study was to investigate the expression and function of microRNA\u2010140 (miR\u2010140) in the process of myocardial I\/R injury. The miR\u2010140 expression level was analyzed in the myocardium with I\/R injury and control myocardium using quantitative real\u2010time polymerase chain reaction. Then the relation between the level of miR\u2010140 and YES proto\u2010oncogene 1 (YES1) was also investigated via luciferase reporter assay. Assessment of myocardial infarct size measurement of serum myocardial enzymes and electron microscopy analysis were used for analyzing the effect of miR\u2010140 on myocardial I\/R injury. We also used Western blot analysis to examine the expression levels of the mitochondrial fission\u2013related proteins, Drp1 and Fis1. miR\u2010140 is downregulated, and YES1 is upregulated after myocardial I\/R injury. Overexpression of miR\u2010140 could reduce the increase related to myocardial I\/R injury in infarct size and myocardial enzymes, and it also could inhibit the expression of proteins related to mitochondrial morphology and myocardial I\/R\u2010induced mitochondrial apoptosis by targeting YES1. Taken together, these findings may provide a novel insight into the molecular mechanism of miR\u2010140 and YES1 in the progression of myocardial I\/R injury. MiR\u2010140 might become a promising therapeutic target for treating myocardial I\/R injury.<\/jats:p>","DOI":"10.1002\/jcb.27663","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T14:03:22Z","timestamp":1538057002000},"page":"3813-3821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["MicroRNA\u2010140 attenuates myocardial ischemia\u2010reperfusion injury through suppressing mitochondria\u2010mediated apoptosis by targeting YES1"],"prefix":"10.1002","volume":"120","author":[{"given":"Shuguo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology Linyi Central Hospital Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haide","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Linyi Central Hospital Linyi Shandong 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