{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:35:07Z","timestamp":1776350107429,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The current study was designed to investigate the effects and underlying mechanisms of adipose tissue\u2010derived stem cells (ADSCs) on hypertrophic scar (HS) fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Real\u2010time quantitative polymerase chain reaction (qRT\u2010PCR) and Western blot analysis were performed to detect the expression of collagen I (Col1), collagen III (Col3), and \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) after fibroblasts and cultured HS tissues were treated with ADSC medium. All data were analyzed by using SPSS17.0 software. Statistical analysis was performed by Student <jats:italic>t<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The in vitro study showed that ADSC medium decreased the expression of Col1, Col3, and \u03b1\u2010SMA. In addition, the protein level of p\u2010p38 was downregulated by ADSC medium treatment in a concentration dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study demonstrated that ADSC could decrease collagen deposition and scar formation in\u00a0in vitro experiments. 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