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DNA\u2010histone connection mediates a wide range of genes that code methylation, demethylation, acetylation, deacetylation, ubiquitination, and phosphorylation enzymes. Epigenetic modifications regulate chromatin compactness, which plays pivotal roles in critical biological processes including the transcriptional activity and cell proliferation as well as various pathological mechanisms, including CML. This study is aimed to determine the alterations of the expression levels of epigenetic modification\u2013related genes after ruxolitinib treatment. Total RNA was isolated from K\u2010562 cells treated with the IC<jats:sub>50<\/jats:sub> value of ruxolitinib and untreated K\u2010562 control cells. A reverse transcription procedure was performed for complementary DNA synthesis, and gene expressions were detected by real\u2010time polymerase chain reaction compared with the untreated cells. Ruxolitinib treatment caused a significant alteration in the expression levels of epigenetic regulation\u2010related genes in K\u2010562 cells. Our novel results suggested that ruxolitinib has inhibitor effects on epigenetic modification\u2013regulator genes.<\/jats:p>","DOI":"10.1002\/jcb.27744","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T12:51:26Z","timestamp":1538052686000},"page":"4555-4563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic modifications in chronic myeloid leukemia cells through ruxolitinib treatment"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-3124","authenticated-orcid":false,"given":"Cigir","family":"Biray Avci","sequence":"first","affiliation":[{"name":"Department of Medical Biology Medical Faculty, Ege University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-7455","authenticated-orcid":false,"given":"Bakiye","family":"Goker 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