{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:27:34Z","timestamp":1792186054120,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone\u2013binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization\u2010embryo transfer (IVF\u2010ET) in PCOS patients. PCOS patients who underwent IVF\u2010ET and patients with non\u2013PCOS\u2010related infertility were selected in the study. Correlations of SHBG rs6259 and rs727428 with the risk factors in PCOS were analyzed, followed by the evaluation of the effect of SHBG polymorphisms on the outcome of IVF\u2010ET in PCOS patients. At last, unconditional logistic regression analysis was performed to study the risk factors for IVF\u2010ET treatment outcome. Compared with SHBG rs6259 GG carriers, the incidence of PCOS was found to be elevated in SHBG rs6259 GA+AA carriers which indicated that the A allele was a risk factor for PCOS. Compared with SHBG rs6259 TT carriers, the number of retrieved oocytes and embryo as well as the fertility rate in SHBG rs6259 GA+AA carriers was found to be decreased, while the abortion rate, incidence of ovarian hyperstimulation syndrome, transplant rejection rate, estradiol, and testosterone in serum, as well as testosterone in follicular fluid were elevated. The luteal hormone, serum testosterone, and progesterone and GA+AA genotype of rs6259 were the risk factors for IVF\u2010ET treatment outcome. Taken together, the study showed that SHBG rs6259 polymorphisms might be correlated with the risk of PCOS and the outcome of IVF\u2010ET treatment.<\/jats:p>","DOI":"10.1002\/jcb.27756","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T04:40:30Z","timestamp":1544071230000},"page":"4675-4686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of sex hormone\u2013binding globulin polymorphisms on the outcome of in vitro fertilization\u2010embryo transfer for polycystic ovary syndrome patients: A case\u2010control study"],"prefix":"10.1002","volume":"120","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics Linyi Central Hospital Linyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Xi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Linyi Central 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