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Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of cancers. It is generally accepted that cellular damage occurs during photo treatment. There is a limitation in using of curcumin as a drug due to its low solubility, but nanoparticles such as anionic nanoclays or layered double hydroxide (LDH) could overcome it. The aim of this study was to investigate cellular responses to curcumin\u2010LDH nanoparticles after photodynamic treatment of MDA\u2010MB\u2010231 human breast cancer cells. For this purpose, the MDA\u2010MB\u2010231 human breast cancer cell line treated with curcumin\u2010LDH nanoparticle and then irradiated (photodynamic treatment). After irradiation, lactate dehydrogenase assay, clonogenic cell survival, cell death mechanisms such as autophagy and apoptosis were determined. Cell cycle distribution after photodynamic therapy (PDT) and also intracellular reactive oxygen species (ROS) generation were measured. The result showed that curcumin\u2010LDH\u2013PDT has a cytotoxic and antiprolifrative effect on MDA\u2010MB\u2010231 human breast cancer cells. Curcumin\u2010LDH\u2013PDT induced autophagy, apoptosis, and G0\/G1 cell cycle arrest in human breast cancer cell line. Intracellular ROS increased in MDA\u2010MB\u2010231 cancer cell line after treatment with curcumin\u2010LDH along with irradiation. The results suggest that curcumin\u2010LDH nanoparticle could be considered as a novel approach in the photodynamic treatment of breast cancer.<\/jats:p>","DOI":"10.1002\/jcb.27775","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T05:46:31Z","timestamp":1539150391000},"page":"4998-5009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Photodynamic treatment with anionic nanoclays containing curcumin on human triple\u2010negative breast cancer cells: Cellular and biochemical studies"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-5031","authenticated-orcid":false,"given":"Khatereh","family":"Khorsandi","sequence":"first","affiliation":[{"name":"Department of Photodynamic, Medical Laser Research Center,YARA Institute, ACECR Tehran 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